Electrophysiology – Multimedia

The results shown here imply that iPSC-derived Cor.4U human cardioymocytes are a translational in vitro cell model for the prediction of clinically relevant drug-induced cardiac arrhythmias and long-term toxicity.

Some Breaking Neuroscience Stories.

HumSilencer removes the most common source of background noise in electrophysiology experiments. This App note explains how.

Michael Nestor gives you a simplistic overview of what equipment you might need or encounter when setting up a single-cell patch clamp rig for whole-cell patch and electrophysiological recordings from neurons.

These results support the use of hSC-CM and MEA technology for preclinical assessment of proarrhythmic risk within the proposed CiPA paradigm, and, more generally, demonstrate that automation of the CM-MEA assay can achieve high reliability and throughput for cardiac risk assessment in vitro.

Simultaneously Recording From Four Neurons Using PatchStar & MicroStar Manipulators.

Description of a straightforward approach to achieving blind paired electrophysiological recordings in vivo

Electrophiles can bind through reversible or irreversible reactions based on the structure of the compound. Here, patch clamp techniques and calcium imaging have been used to characterize human TRPA1 (hTRPA1) channel activity (expressed in HEK293 cells) in the presence of reversible and irreversible electrophiles

This protocol describes the preparation of hippocampal slice and electrophysiology recording.

This presentation will describe the critical role of human stem cell derived cardiomyocytes in the CiPA initiative, lessons learned as the project moves towards completion, along with their future role in preclinical cardiac safety testing.