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Neurodegeneration – Multimedia

Metabolomic profile of multiple sclerosis patients by means of 1H-NMR analysis content piece image
Poster

Metabolomic profile of multiple sclerosis patients by means of 1H-NMR analysis

Multiple sclerosis (MS) is a chronic disease characterized by a high level of heterogeneity. Metabolomics is an “-omics” approach with the potential to discover new biomarkers.
A New Dual Luciferase Assay Using NanoLuc® Enables a Second Generation Coincidence Reporter System to Reduce False Hits in HTS Poster content piece image
Poster

A New Dual Luciferase Assay Using NanoLuc® Enables a Second Generation Coincidence Reporter System to Reduce False Hits in HTS Poster

Luciferase-based reporter-gene assays remain a cornerstone of high-throughput screening of compounds because of their high sensitivity and dynamic range. However, a substantial number of non-relevant hits can be generated due to direct interaction of compounds with the luciferase reporter.
Knockdown of p53 by Accell Self-delivering siRNA Causes Inhibition of p53-dependent DNA Damage Response in IMR-32 Neuroblastoma Cell Line and β-amyloid Toxicity in Rat Cortical Neurons  content piece image
Poster

Knockdown of p53 by Accell Self-delivering siRNA Causes Inhibition of p53-dependent DNA Damage Response in IMR-32 Neuroblastoma Cell Line and β-amyloid Toxicity in Rat Cortical Neurons

Here we describe how application of Accell siRNA enabled the development of a high content screening assay in IMR-32 neuroblastoma cells and a whole culture cell viability assay in primary rat cortical neurons.
Alzheimer's Disease Model Cells Derived from Human iPS Cells content piece image
Poster

Alzheimer's Disease Model Cells Derived from Human iPS Cells

Alzheimer's disease model neurons were created from iPS cells to enable functional, cell-based assays for AD.
Video

Biomarkers from Discovery to Clinical Diagnostics Applications of Single-Molecule Array (Simoa) Technology

Andreas Jeromin, Atlantic Biomarkers, speaking at Diagnostics & Biomarkers 2015.
Recent Foodomic Developments to Investigate the Bioactivity of Dietary Ingredients content piece image
Video

Recent Foodomic Developments to Investigate the Bioactivity of Dietary Ingredients

In this work, we will present the fundamentals of Foodomics, discussing the role of this new discipline to solve some current and future challenges in food science and nutrition, and showing several Foodomics applications carried out in our laboratory related to food quality and food bioactivity.
Fighting Blindness with 3D-NET "Drug Discovery & Development of Novel Eye Therapeutics" content piece image
Poster

Fighting Blindness with 3D-NET "Drug Discovery & Development of Novel Eye Therapeutics"

3D-NET, “Drug Discovery & Development of Novel Eye Therapeutics”, is a new European research consortium of industry and academic partners focusing efforts to enhance the discovery and development of drugs targeting ocular pathologies that lead to blindness.
Liposomes and Nanoparticles as Delivery Vehicles for the Treatment of Lung Diseases content piece image
Poster

Liposomes and Nanoparticles as Delivery Vehicles for the Treatment of Lung Diseases

Targeted nanoparticle-based drug delivery to the lungs is an emerging area of interest for both scientists and medical workers because it allows better drug retention in the lungs and can provide prolonged drug release. In our study we investigated the potential of using liposomes and polymeric nanoparticles surface modified with a specific antibody as drug carriers for targeted drug delivery to the lungs.
Huntington's Disease And Forensic Risk Factors In Females content piece image
Poster

Huntington's Disease And Forensic Risk Factors In Females

The following case series documents three females admitted to an in-patient unit. All three females had positive HD gene tests and all three had diverse forensic histories. It is recognised that males with HD have an increased forensic risk (Jensen, 1998) but these three cases highlight that HD may also be a forensic risk factor in females.
Random Homozygous Gene Perturbation (RHGP) as a Tool for Target Discovery and Validation content piece image
Poster

Random Homozygous Gene Perturbation (RHGP) as a Tool for Target Discovery and Validation

Random homozygous gene perturbation (RHGP) can identify and validate any host (cellular) gene target that directly causes a desired phenotype without requiring prior knowledge of the target. The central feature of RHGP is a unique lentiviral-based genetic element, known as a gene search vector (GSV) designed to interrogate the entire genome and identify target genes that cause the phenotype of interest.
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