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Neurodegeneration – News and Features

Drugs of different colors, shapes and sizes in half-filled blister packs.

Blood Clot-Targeting Drug Candidates Developed Through Computer-Aided Design

A team of researchers has created a new series of drug candidates against a hard-to-target receptor involved in the formation of blood clots.
Bacteria in the gut.

Transplanting Gut Microbes From Aged Mice Induces Age-Related Inflammation

When the gut microbes of aged mice were transplanted into young, germ-free mice, the recipients experienced an increase in inflammation, suggesting that the gut microbiome plays a role in the inflammation that occurs with aging.
Neural networks of the human brain; a 3D illustration.

Huntington’s Disease Impacts Brain Blood Vessels Even Before Symptoms Appear

The genetic disease Huntington’s not only affects nerve cells in the brain but also has widespread effects on microscopic blood vessels according to research.
Neural connections.

Chilled Brain Molecules Unravel Epilepsy Drug’s Mechanism

Scientists at Johns Hopkins Medicine say they have determined how a widely-used epilepsy drug works to dampen the excitability of brain cells and help to control, although not cure, seizures.
A human brain in purple.

Scientists Investigate Resting Tremor in Parkinson’s Study

A study from Murdoch's Centre for Healthy Ageing, investigated the connectivity between brain regions important for voluntary movement control in individuals with Parkinson’s disease, both on and off dopamine medication.
A pile of blue pills on a yellow background.

Erectile Dysfunction Drug May Improve Brain Blood Flow and Help Prevent Dementia

A new trial conducted by the University of Oxford reveals that sildenafil, commonly known as Viagra, enhances blood flow to the brain and improves the function of brain blood vessels in patients at a heightened risk of vascular dementia.
Image of a virus showing the spike proteins on the surface of the virus

Immune System “Misdirection” May Explain Link Between Epstein-Barr Virus and MS

Research from the University of Birmingham has found that following EBV infection there is more immune system cross-reactivity, where the body’s immune system binds to the wrong target, than previously thought.
Neurons degenerating.

Long-Read Sequencing Identifies RNA Isoforms in Alzheimer’s Patients

Researchers at the University of Kentucky Sanders-Brown Center on Aging are working to develop a pre-symptomatic disease diagnostic tool for Alzheimer’s disease.
Close-up photograph of a person's mouth smiling

Opportunistic Bacteria Are More Abundant in the Microbiome of Mouthwash Users

After three months of daily use of an alcohol-based mouthwash, two species of opportunistic bacteria were significantly more abundant in the mouth. These findings provide evidence that mouthwash may have a detrimental effect on the oral microbiome.
The octo-patch rig is a specialized microscope allowing neuroscientists to record electrical properties from and map connections between up to eight neurons simultaneously.

Neuronal Response to Electrical Stimulation Is Not Uniform

New research offers an unprecedented look at how neurons respond to electric stimulation. Far from being uniform, different types of neurons showed distinct patterns of ‘syncing up’ with electrical fields.