Neurodegeneration – News and Features

Researchers discovered a particular protein (known as OSER1) when they studied a larger group of proteins regulated by the major transcription factor FOXO, known as a longevity regulatory hub.

A new study reveals that neighboring synapses compete for molecular resources during plasticity. This competition affects their ability to strengthen connections and influences memory formation.

A new study reveals that hormone therapy (HT) affects biological aging in postmenopausal women. Starting HT before age 45 accelerates aging, while starting after age 45 slows it down.

Researchers identified the nucleolar protein PQBP3 as key in linking aging to neurodegenerative diseases. The study shows PQBP3's relocation during cellular senescence disrupts nuclear membrane stability.

Researchers have uncovered that the protein PRDM1-S disrupts immune regulation in multiple sclerosis and other autoimmune diseases by increasing the enzyme SGK-1. This finding provides insight into the molecular mechanisms behind these conditions.

A machine-learning tool can help distinguish subtypes of rheumatoid arthritis, which may help scientists find ways to improve care by detecting unexpected tissue changes that humans might miss.

A new study reveals that Tau – a protein implicated in several neurodegenerative conditions including Alzheimer’s disease – also plays a positive role in the brain.

Researchers found that androgen deprivation therapy (ADT) for prostate cancer may increase Alzheimer’s risk by damaging the blood-brain barrier and promoting brain inflammation.

A new study introduces an advanced cortisol detector using iridium oxide nanoparticles, enhancing stability and sensitivity. This low-cost, high-performance device accurately measures cortisol levels at home.

Researchers add new evidence to the emerging concept that "silent" mutations may have crucial consequences, showing how a synonymous mutation in one gene can significantly affect a neighboring gene, increasing its protein production.