Neurogenomics – News and Features

A new study has revealed that FOXR2 activation occurs in multiple brain tumor types, not just CNS neuroblastoma. This discovery could improve the diagnosis, prognosis and treatment of brain tumors.

A team from Fujita Health University developed a computational model to simulate the formation of protein condensates at synapses, revealing how proteins like CaMKII help organize memory structures in the brain.

Researchers at Tokyo University of Science have developed Chol-HDOs, which efficiently penetrate the brain, overcoming challenges associated with delivering gene-targeting drugs to brain tissue.

A UCLA-led study reveals that children with chromosome 22q11.2 deletion syndrome show brain hyperconnectivity before puberty and under-connectivity after. This shift, linked to synapse loss, may drive autism and schizophrenia risk.

A study reveals that the HDAC5 enzyme regulates the gene Scn4b, which affects neuronal activity in the brain's reward regions. This regulation helps form long-lasting drug memories and contributes to relapse in cocaine use disorder.

The detection of peripheral neural stem cells could transform the treatment of Parkinson's disease and spinal cord injuries.

Researchers at the Icahn School of Medicine have discovered mutations in the non-coding gene RNU2-2 as a new cause of neurodevelopmental disorders. This highlights the role of non-coding genes in these conditions.

Researchers have dosed the first participant in a clinical trial of an investigational medicine designed to lower the amount of amyloid precursor protein for the potential treatment of Alzheimer’s disease.

A new study provides insights into Tourette syndrome by analyzing individual brain cells. Researchers found key changes, including a loss of interneurons, metabolic stress in medium spiny neurons, and increased inflammatory activity in microglia.

Researchers at UCSF discovered that regulatory T cells (T-regs) in the meninges produce natural opioids, and their pain-suppressing effects are influenced by estrogen and progesterone.