Neurogenomics – News and Features

The detection of peripheral neural stem cells could transform the treatment of Parkinson's disease and spinal cord injuries.

Researchers at the Icahn School of Medicine have discovered mutations in the non-coding gene RNU2-2 as a new cause of neurodevelopmental disorders. This highlights the role of non-coding genes in these conditions.

Researchers have dosed the first participant in a clinical trial of an investigational medicine designed to lower the amount of amyloid precursor protein for the potential treatment of Alzheimer’s disease.

A new study provides insights into Tourette syndrome by analyzing individual brain cells. Researchers found key changes, including a loss of interneurons, metabolic stress in medium spiny neurons, and increased inflammatory activity in microglia.

Researchers at UCSF discovered that regulatory T cells (T-regs) in the meninges produce natural opioids, and their pain-suppressing effects are influenced by estrogen and progesterone.

Researchers at the University of Texas at Arlington discovered how the flowerpot snake, with three sets of chromosomes, can reproduce without a mate. The study uncovers the snake’s DNA repair mechanisms.

A recent study demonstrated the potential of gene therapy to restore motor capacity in an ultra-rare disease, megalencephalic leukoencephalopathy with subcortical cysts (MLC), even when treatment begins after symptom onset.

Discover how RNA therapeutics are reshaping medicine, offering new treatments for previously undruggable targets.

Researchers have developed a laboratory model that mimics the pathological aggregation of TDP-43, a key protein in ALS and frontotemporal dementia. The model, based on human cells, recapitulates TDP-43’s mislocalisation and aggregation.

Soleno Therapeutics today announced that the US FDA has approved VYKAT XR (diazoxide choline) extended-release tablets, for the treatment of hyperphagia in adults and children four years of age and older with Prader-Willi syndrome.