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Neurogenomics – News and Features

Bright staining highlights VIP-expressing interneurons in this coronal cross-section of a mouse brain. The neurons may help drive glymphatic clearance of amyloid via the release of peptides.

How Does 40Hz Sensory Gamma Rhythm Stimulation Clear Amyloid?

Stimulating a key brain rhythm with light and sound increases peptide release from interneurons, driving clearance of Alzheimer’s protein via the brain’s glymphatic system, new study suggests.
A strand of DNA.

Single Gene Linked to Social Skills Variability

Researchers have pinpointed a single gene that is linked to variability in social skills, from the extreme social strengths of William's syndrome to the social struggles of people with autism.
A woman sits cross-legged on grass.

Kundalini Yoga Provides Unique Cognitive Benefits to Older Women

Kundalini yoga, which focuses on breathwork and meditation, can provide several benefits to cognition and memory in older women at risk of developing Alzheimer's disease.
A woman smelling flowers.

Sniffing Out Surprises Could Shape the Future of Health and Agriculture

Imagine if we could inhale scents that delay the onset of cancer, inflammation, or neurodegenerative disease. Researchers at the University of California, Riverside, are poised to bring this futuristic technology closer to reality.
Neurons and their connections shown in red and yellow, with cell nuclei shown in blue.

Trabid Protein’s Role in Microcephaly Identified for the First Time

A new study pinpoints how mutations in a protein involved in neuronal development can contribute to microcephaly, which causes abnormal brain development.
The activity of Snhg11 (red) pictured in the dentate gyrus region of the hippocampus in mice.

Down Syndrome Memory Challenges Tied to Genome's "Dark Matter"

Researchers reveal that the Snhg11 gene is critical for the function and formation of neurons in the hippocampus. Experiments with mice and human tissues revealed the gene is less active in brains with Down syndrome.
A sea lamprey with its suction cup mouth and razor-sharp teeth.

Sea Lampreys Rewrite Our Understanding of Vertebrate Brain Evolution

A new study from the Krumlauf laboratory shows that the hindbrain of humans and jawless sea lamprey is built using a similar molecular and genetic toolkit. This discovery implies that these molecular features were present in the common ancestor of all vertebrates today.
A man and his dog.

Human and Canine Meningiomas Are Genetically Similar

Researchers have discovered genetic similarities between common brain tumors in humans and dogs, opening the door for collaborations between human and animal medicine.
Laughter between an older and younger male.

Ancient DNA Reveals Down Syndrome in Historical Populations

A new study scoured ~10,000 ancient genomes in search of trisomies, such as Down Syndrome. Combined with archeological analyses, the data reveal how these infants were perceived in ancient societies.
A tangle of neurons.

Ancient Retroviruses Supported the Evolution of Vertebrate Brains

A retrovirus-derived genetic element is to thank for myelin production – and by extension, large brains – in vertebrates.