Pharmacovigilance – News and Features

News
Researchers Find Better Treatment for Rare Pregnancy-Related Cancer
Scientists have found a way to combat a rare, aggressive form of cancer affecting pregnant women and to better ensure the drug used for the disease reaches tumor cells without damaging healthy tissue.

News
Cancer Vaccine Shows Promise for Advanced Kidney Cancer
A phase 1 trial of a personalized cancer vaccine for stage III/IV clear cell renal cell carcinoma showed promising results. The vaccine trained patients’ immune systems to target cancer cells, preventing recurrence.

News
Study Finds No Evidence CAR T-Cell Therapy Causes Secondary Cancers
A study of 783 patients treated with CAR T cell therapy found no evidence that the therapy itself caused secondary cancers. Researchers confirmed that rare cases of cancer were linked to prior treatments like chemotherapy, not CAR T therapy.

News
Gene Therapy Shows Promise for Rare Bone Disease in Mice
Researchers have developed a gene therapy that may provide a long-term treatment for hypophosphatasia. Unlike current therapies requiring frequent injections, this approach delivers a single dose to restore bone mineralization.

News
ApoB100's Shape and Structure Revealed for the First Time
Using cryo-electron microscopy and AI, researchers at the University of Missouri have mapped ApoB100, a key protein in LDL cholesterol. This offers a clearer understanding of cholesterol metabolism.

News
Lisdexamfetamine Shows Mixed Results for Binge Eating Disorder
Rutgers researchers found that lisdexamfetamine reduces binge episodes in binge eating disorder patients but has notable side effects, including insomnia and afternoon energy crashes.

News
Targeted Therapy Shows Effectiveness in Skin Disease Patients
Mayo Clinic researchers have identified a targeted therapy that could bring relief to people living with lichen planus, a chronic inflammatory skin condition of the skin, hair, nails, mouth and genitals.

News
Low Doses of Oral Ketamine Can Reduce PTSD Symptoms, Study Suggests
A new study finds that oral ketamine significantly reduces PTSD symptoms, with 73% of participants seeing a 50% reduction in symptoms. The treatment, taken as a liquid drink, was well-tolerated and had fewer side effects than intravenous ketamine.

News
How an Effective Cancer Therapy Was Redesigned To Make It Safer
UIC researchers have redesigned asparaginase, a key leukemia treatment, to reduce severe side effects like liver damage and blood clots. The modified enzyme is more effective and may treat other cancers like melanoma.

Article
Weight Loss and Diabetes Drugs: What’s the Latest Research?
Studies have suggested that GLP-1RAs may show promise for a host of conditions, from alcohol use disorder to Parkinson’s. But reports of unpleasant side effects have prompted further studies. This article explores the latest research on these drugs.
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