Why Current Pain Models Continue to Fail Translation
Webinar
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Current preclinical pain models frequently fail to reproduce the complexity and heterogeneity of human disease, limiting confidence in translational research and therapeutic development.
This webinar examines how human iPSC-derived nociceptor models, integrated with patient-derived biological samples, can improve biological relevance for osteoarthritis research. Dr. Ryan Jones will discuss multicompartment culture systems alongside functional electrophysiology, including microelectrode arrays and high-throughput patch clamp, to investigate neuron–tissue interactions and pain signaling.
The session will also explore how these human-specific in vitro approaches support the broader transition toward predictive human-specific alternatives to animal models for drug discovery.
Attend this webinar to:
- Understand how patient-derived samples are incorporated into human pain models
- Explore where microelectrode arrays and high-throughput patch clamp add biological insight
- Identify which experimental limitations still remain in current pain models
- Gain insight into where these systems are already improving translational confidence
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