Addressing The Needs Of Drug Discovery With The MicroCal PEAQ-ITC Instruments
White Paper Apr 01, 2015
Malvern Instruments Limited
Measurements and characterization of binding interactions between proteins and low-molecular weight ligands are fundamental for drug discovery. Among the most recognized challenges in characterizing binding interactions are (1) the need to accurately assess a wide span of binding affinities (KD) and (2) accurately rank and characterize low-molecular weight (LMW) ligands based on affinity, mechanism of action, and energetics of interaction.
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