Latest Whitepapers
Whitepaper
Plan for Success in Gene and Cell Therapy Manufacturing
This whitepaper highlights essential factors to consider for the successful manufacturing of gene and cell therapies.
Whitepaper
Spin It First: Solutions for Better Bioprocessing
High-intensity, high-volume cell cultures are an essential part of many bioproduction workflows – especially those operating at scale. However, aggregate accumulation, batch-to-batch cleaning and extensive sterility validation can all negatively impact overall workflow efficiency.
Whitepaper
Prep for Success With Quality Liquids and Buffers
The preparation of process liquids and buffers for in-house bioprocessing can be complex and face many logistical challenges. Additionally, a failure to optimize operational efficiency can result in supply chain disruption, total cost of ownership (TCO) and quality control challenges.
Whitepaper
Reducing Risk With Production Chemical and Sourcing Services
This case study highlights how a CDMO at risk of a facility shutdown solved severe supply disruption problems with the help of an experienced sourcing service.
Whitepaper
Discover Single-Use Fermenters for Biopharmaceutical Production
Single-use fermenters (SUFs) use disposable sterile plastic bags that don’t require the traditional high-intensity preparation of SS bioreactors, which are expensive and time-consuming processes.
Whitepaper
UHPLC-MS Grade Solvents for Trace Level Analysis and Research Method Assays
Ultra-high performance liquid chromatography (UHPLC) involves utilizing columns with submicron-sized particles and high-pressure flow, resulting in enhanced resolution and sensitivity when dealing with complex sample mixtures. Mass spectrometry (MS) plays a vital role in detecting and identifying analytes even at concentrations as low as parts per trillion.
Whitepaper
Optimizing Mobile Phase Solvent Purity for LC-MS
Liquid chromatography mass spectrometry (LC-MS) plays a pivotal role in the precise analysis of trace molecules. To enhance sensitivity and accuracy, it is crucial for researchers to upgrade from HPLC-grade solvents to LC-MS grade solvents that are specially designed to meet the stringent requirements of modern LC-MS systems.
Whitepaper
Discover Biolayer Interferometry as an AAV Analytics Solution
Adeno-associated viral vector (AAV) has become a preferred gene therapy delivery modality; however, AAV manufacturing is not without its challenges, whether that is using crude samples, a lack of standardized methods or incompatible techniques.
Whitepaper
A Breakthrough Solution for AAV Manufacturing Challenges
Despite the success of AAV for gene therapies and vaccines, many challenges still exist within AAV manufacturing. To ensure the safety and efficacy of a therapeutic, it is crucial to accurately determine the percentage of capsids that carry the gene of interest.
Whitepaper
Benefits of AGT Culture Media in Gene Therapy Applications
A scalable and robust solution for all stages of the gene therapy workflow to meet regulatory standards is essential, however, as the field is more recent, liquid media is the common format even though it can be more expensive and have a shorter shelf life.
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