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Unlocking the Secrets of Brain Organization -in the Fruit Fly

Article

As many people spent the summer trying to keep the flies away from their fruit-bowls, an international group of scientists published one of the biggest and most important datasets in the field of connectomics to date, the complete 3D electron micrograph volume of the fruit-fly (Drosophila melanogaster) brain.

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Neuroscience at Super-Resolution [Image Gallery]

List

A gallery of beautiful images of brain cells at the sub-micron level.

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A Pioneering Peek into the Awake Brain

News

Three-photon microscopy recently emerged as a technique that could give neuroscientists a deeper look at brain cells than ever before. Now, based on a substantial refinement of the technology, scientists at MIT have conducted the first-ever study of stimulated neural activity in an awake mouse through every visual cortex layer and notably the mysterious “subplate” below.

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Top Science Stories of 2018

Video

We have seen some amazing scientific breakthroughs in 2018. Here is a selection of our favorites.

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Defective Glial Cells Can Push Neurons Toward Parkinson's Disease

Defective Glial Cells Can Push Neurons Toward Parkinson's Disease

News

Scientists have discovered that defective astrocytes are linked to the buildup of a toxic protein that is one the hallmarks of Parkinson's disease. The studied astrocytes, derived from Parkinson's disease patients with a genetic mutation that affects cell clean-up functions, caused more accumulation of the toxin, α -synuclein, than those derived from healthy individuals.

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Interference with Estrogen Signaling Sends Bone Formation into Overdrive
News

Deleting a certain type of estrogen receptor in an area of the hypothalamus dramatically increased bone density and strength in female mice, opening up many therapeutic possibilities for improving women's health.

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Now Anyone Can Tour the Fly Brain
News

A new fly-through of the fly brain allows anyone to whizz past neurons and visit any of the 40 million synapses where neurons touch neuron. It’s a super-resolution view of the complex network connections in the insect’s brain that underlie behaviors ranging from feeding to mating.

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Memories of Meals Influence Future Eating Behavior
News

Brain cells involved in memory play an important role after a meal in reducing future eating behavior, a finding that could be key in understanding and fighting obesity, according to a study led by Georgia State University.

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Microglia Transmit Pain to the Brain During Stress

Microglia Transmit Pain to the Brain During Stress

Article

Chronic pain is a multifaceted disorder that causes profound disability worldwide. It has long been known that psychological stress contributes to adverse chronic pain outcomes in patients, but it is unclear how this is initiated or amplified by stress. Now, researchers have published results showing that activation of microglia in the mouse spinal cord is responsible for increased pain sensitivity in response to stress.

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Case Study: Dr. Kaelberer Validates a Neuroepithelial Circuit using Milo
Article

How does the gut talk to the brain? In this new case study from ProteinSimple, we find out how Melanie Maya Kaelberer, a Postdoctoral Associate at Duke University, is using Single-Cell Western platform Milo to answer the question of how the gut can rapidly communicate with cranial nerves.

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A (Lab)Step Towards Reproducible Science
Article

The reproducibility crisis is holding back science. London-based Labstep, a start-up out of Oxford University, think that their tool can help make science more open and reproducible. That claim has now been given some concrete evidence with the announcement that the research contingent of the MRC Unit The Gambia at LSHTM will be trialling Labstep across their Banjul-based facility.

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