Cryo electron microscopy (cryo EM) has revolutionized our understanding of the intricate molecular machinery that governs life. In this article, we discuss what cryo EM is, how it works, it's strengths, limitations and applications.

Our knowledge of how pathological proteins like amyloid spread and become deposited throughout the brain in many major neurodegenerative diseases is now extensive. Nevertheless, our improved understanding of Alzheimer’s molecular mechanisms has yet to bridge over to effective treatments that reverse disease progress. Are we any closer to a cure?

This guide highlights the four major stages of targeted protein degradation, the challenges at each step, and the questions you should ask yourself to ensure your final product will result in a complete protein degradation.

Download this guide to discover how data integrity is fundamental to quality assurance, process development and production, and analytical development and quality control.