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Customizing The Exome

Webinar

The introduction of exome analysis provides the opportunity to improve more findings compared to traditional genetic testing approaches and fixed panel-based genomic analyses. Large studies of many families using trio exomes and a genotype first approach have been incredibly powerful tools for gene discovery and identification of pathogenic variants in rare Mendelian disorders. Proband only exomes, however, require different methods of variant filtering which typically involve prioritisation of genes and/or variants based on phenotype.

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Neuroscience at Super-Resolution [Image Gallery]

List

A gallery of beautiful images of brain cells at the sub-micron level.

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Streamline your western blotting workflow with iWestern

Featured Product

Designed to address processing efficiency, reproducibility, and robustness of results, the iWestern Workflow helps to enable exceptional western blot results with minimal hands-on time.

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Unlocking the Secrets of Brain Organization -in the Fruit Fly

Article

As many people spent the summer trying to keep the flies away from their fruit-bowls, an international group of scientists published one of the biggest and most important datasets in the field of connectomics to date, the complete 3D electron micrograph volume of the fruit-fly (Drosophila melanogaster) brain.

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Pain is a Self-Fulfilling Prophecy

Pain is a Self-Fulfilling Prophecy

News

Expect a shot to hurt and it probably will, even if the needle poke isn’t really so painful. Brace for a second shot and you’ll likely flinch again, even though—second time around—you should know better. That’s the takeaway of a new brain imaging study which found that expectations about pain intensity can become self-fulfilling prophecies.

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Researchers Find Inhibiting One Protein Destroys Toxic Clumps Seen in Parkinson's Disease
News

“To our knowledge, these data are the first to elucidate the role of USP13 in neurodegeneration.”

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Drug Candidate Could Recover Vocal Abilities Lost to ADNP Syndrome
News

A new Tel Aviv University study finds that the drug candidate CP201, also known as NAP, may improve vocal communication abilities that are underdeveloped in Activity-dependent neuroprotective protein (ADNP) patients.

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Molecular Mechanisms of Ancient Herbal Remedies
News

Analysis of leaf extract reveals novel chemistry for therapeutic ion channel activation.

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The Brain Bounces Back: Activity enables mice to overcome brain damage

The Brain Bounces Back: Activity enables mice to overcome brain damage

Article

Scientists removed an area of the somatosensory cortex in mice and found the animals could recover their behavioral deficit within two days.

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'Microdosers' of LSD and Magic Mushrooms are Wiser and More Creative
Article

Researchers just ran the first ever pre-registered scientific study on the microdosing of psychedelics and found some very promising results.

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Inflamyloid: What Is It and Why Is It Important in Alzheimer's Disease?
Article

Alzheimer’s disease (AD) is the leading cause of dementia worldwide. Classically, the “amyloid” hypothesis, which ties the disease’s spread to that of amyloid protein, is thought to underlie AD’s pathology. After years of mixed to negative results in clinical trials, new research is underway to investigate what role the brain’s own immune system plays in amyloid-driven disease; an “infl-amyloid” hypothesis.

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Through the Looking Glass of Single Cell Proteomics
Article

To pick apart the differences between individual cells in complex multicellular organisms, we need to look at cells one-by-one. This article takes a look at how several scientists in North America are using single cell proteomics (SCP) technologies to discern disease pathogenesis and enhance directed stem-cell differentiation.

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