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Imaging the Brain at High Spatiotemporal Resolution

Webinar

Physics has long employed optical methods to probe and manipulate matter on scales from the infinitesimal to the immense. To understand the brain, we need to monitor physiological processes of single synapses as well as neural activity of a large number of networked neurons. Optical microscopy has emerged as an ideal tool in this quest, as it is capable of imaging neurons distributed over millimeter dimensions with sub-micron spatial resolution.

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How to Analyze Images with Invitrogen iBright Imaging Systems

Video

Capture images and analyze data from your western blots and gels efficiently and easily using the Invitrogen iBright Imaging Systems.

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Neuroscience at Super-Resolution [Image Gallery]

List

A gallery of beautiful images of brain cells at the sub-micron level.

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Unlocking the Secrets of Brain Organization -in the Fruit Fly

Article

As many people spent the summer trying to keep the flies away from their fruit-bowls, an international group of scientists published one of the biggest and most important datasets in the field of connectomics to date, the complete 3D electron micrograph volume of the fruit-fly (Drosophila melanogaster) brain.

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The Surprising Role of the Cerebellum in Reward and Social Behaviors

The Surprising Role of the Cerebellum in Reward and Social Behaviors

News

A new study in rodents has shown that the brain’s cerebellum—known to play a role in motor coordination—also helps control the brain’s reward circuitry. Researchers found a direct neural connection from the cerebellum to the ventral tegmental area (VTA) of the brain, which is an area long known to been involved in reward processing and encoding.

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New Role for Microvessels in Spinal Cord Injury
News

Previously unidentified roles have been established for endothelial cells: they engulf myelin debris following spinal cord injury, and contribute to the progression of inflammation, angiogenesis, and possibly, fibrotic scar formation.

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When Memory Loss Could Just Be Hearing Loss
News

A recent study published in the Canadian Journal on Aging, found that the majority of participants being evaluated for memory and thinking concerns and potential brain disorders had some form of mild to severe hearing loss, but only about 20 per cent of individuals used hearing aids. Among the participants, a quarter of them did not show any signs of memory loss due to a brain disorder.

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Neurofilament Light Change Dynamics: Alzheimer's Diagnostics Progress
News

A simple blood test reliably detects signs of brain damage in people on the path to developing Alzheimer’s disease – even before they show signs of confusion and memory loss, according to a new study from Washington University School of Medicine in St. Louis and the German Center for Neurodegenerative Diseases in Germany.

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Case Study: Dr. Kaelberer Validates a Neuroepithelial Circuit using Milo
Case Study: Dr. Kaelberer Validates a Neuroepithelial Circuit using Milo
Article

How does the gut talk to the brain? In this new case study from ProteinSimple, we find out how Melanie Maya Kaelberer, a Postdoctoral Associate at Duke University, is using Single-Cell Western platform Milo to answer the question of how the gut can rapidly communicate with cranial nerves.

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Microglia Transmit Pain to the Brain During Stress
Microglia Transmit Pain to the Brain During Stress
Article

Chronic pain is a multifaceted disorder that causes profound disability worldwide. It has long been known that psychological stress contributes to adverse chronic pain outcomes in patients, but it is unclear how this is initiated or amplified by stress. Now, researchers have published results showing that activation of microglia in the mouse spinal cord is responsible for increased pain sensitivity in response to stress.

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A (Lab)Step Towards Reproducible Science
A (Lab)Step Towards Reproducible Science
Article

The reproducibility crisis is holding back science. London-based Labstep, a start-up out of Oxford University, think that their tool can help make science more open and reproducible. That claim has now been given some concrete evidence with the announcement that the research contingent of the MRC Unit The Gambia at LSHTM will be trialling Labstep across their Banjul-based facility.

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Understanding the Role of BDNF on GABAergic neurotransmission
Understanding the Role of BDNF on GABAergic neurotransmission
Article

Researchers have identified a mechanism by which brain-derived neurotrophic factor (BDNF) can suppress GABAergic transmission in hippocampus. In this article, Dr. Rajamani Selvam explains how he and his team achieved these results, and their potential impact on the treatment of neurological disease.

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Light Sheet Imaging Helps Capture Zebrafish Neural Development
Light Sheet Imaging Helps Capture Zebrafish Neural Development
Article

A video showing the birth of an incredible network of neurons in the nervous system of a Zebrafish has won first prize at the Nikon Small World in Motion Awards, which highlight the best in photography and video captured through the microscope lens. We caught up with researchers behind the video to find out more.

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