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Latest App Notes & Case Studies

3D illustration of X-ray Imaging of a Human Brain with a Brain Tumor stock photo
App Note / Case Study

Automated, Label-Free Imaging and Analysis of Neuronal Cultures

This application note showcases the use of label-free imaging techniques for live-cell analysis of neuron culture outgrowth in an iPSC-derived glutamatergic cell model.
Microscopic view of fluorescently labeled cells showing green cell bodies with blue nuclei connected by thin, bridge-like structures
App Note / Case Study

Studying the Link Between Cell Migration and Neurodegenerative Disease With iPSC-derived Microglia

In this application note, researchers from Medicines Discovery Catapult (MDC) evaluated the suitability of iPSC-derived microglia as a model for studying the mechanics of microglia activation, shedding light on their role in neurodegeneration and the potential for therapeutic targets.
A doctor writing on a clipboard next to a brain, examining medical records and analyzing brain functions
App Note / Case Study

Improving Physiological Relevance in Neurological Disease Drug Development

This app note explores the use of human iPSC-derived microglial cells as a more reliable model for neurobiological drug development.
Lab Experimen
App Note / Case Study

A High-Throughput Platform for Fluorescence Image-Based Neurite Outgrowth Analysis

This application note introduces an automated solution for flexible and sensitive multichannel analysis of neurite outgrowth for high-throughput assays.
Neuro Research
App Note / Case Study

Speeding Up Neuroscience Research

Delve into this case study to explore how a research lab at King’s College London used hiPSC-derived neurons to shed light on synaptic biology and potential treatments for psychiatric conditions.
Neuro Program
App Note / Case Study

Precision Reprogrammed iPSC Models for High-Throughput Drug Discovery

This app note delves into the role of TDP-43 protein aggregates in the disease's progression. Charles River Laboratories and bit.bio present a breakthrough in ALS research with genetically matched ioGlutamatergic Neurons, providing a crucial in vitro model.
Sensitive Bioanalysis of Biomarkers in Cerebral Spinal Fluid
App Note / Case Study

Enhancement of Sensitive Bioanalysis of Biomarkers in Cerebral Spinal Fluid

This app note highlights a highly sensitive method developed for the detection of GalSPH and GluSPH in CSF.

Detecting Systemic Interindividual Epigenetic Variation content piece image
App Note / Case Study

Detecting Systemic Interindividual Epigenetic Variation

Studying DNA methylation at correlated gene regions can provide researchers with insights into disease-associated epigenetic variation. Hence, cost-effective sequencing is essential for our advancement and understanding of epigenetic epidemiology.
Developing Next-Generation <i>In Vitro</i> Phenotypic Assays for Huntington’s Disease content piece image
App Note / Case Study

Developing Next-Generation In Vitro Phenotypic Assays for Huntington’s Disease

There is currently no effective cure or treatment to slow down or stop the progression of Huntington's disease (HD). One reason for this is the lack of accurate and easy-to-use HD models.
Progress Towards Out-of-the-Box Sub-Cellular Imaging content piece image
App Note / Case Study

Progress Towards Out-of-the-Box Sub-Cellular Imaging

Single cell analysis in a spatially resolved context is the gateway to deciphering scientific questions in various application areas. Such analysis requires the highest available spatial precision combined with highly sensitive detection.
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