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Application Notes

 
Enhancing Micro-Flow Ionization in Mass Spectrometry
Application Note

Download this tech note to learn how you can enhance your ionization, sensitivity, ion uptake efficiency and robustness when performing micro-LC/MS.

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Normalization in Western Blotting to Obtain Relative Quantitation
Application Note

Download this free technical note to discover the principles of normalization using internal loading controls, and how to accurately normalize your western blot.

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Thermal Cycler Temperature Accuracy – A Comparison of Different Models
Application Note

Download this application note to learn about thermal cycler temperature performance across different models, against manufacturers’ published specifications, and in isothermal, VeriFlex™, and gradient mode.

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A Continual Trials Approach to Spontaneous Object Recognition in Mice
Application Note

Tasks of spontaneous recognition are widely used to assess memory in rats and mice.

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Visualization of Membrane Dynamics with Millisecond Temporal Resolution
Application Note

Electrical stimulation of neurons combined with high-pressure freezing allows physiological activation of synaptic activity and precise control over the time frame of the inducted synaptic activity.

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Quantitative live-cell analysis for optimization of culture conditions and evaluation of cell health in human induced pluripotent stem cell-derived neurons
Application Note

In this application note, we describe methods and present validation data highlighting optimal culture conditions for evaluation of cell viability and neurite outgrowth in hiPSCderived neurons from Cellular Dynamic International.

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HumSilencer Eliminates Electrical Hum Without Causing Signal Distortion
Application Note

HumSilencer removes the most common source of background noise in electrophysiology experiments. This App note explains how.

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Visualizing Subcellular Vesicles to Quantitate Autophagy in Neuronal Cells
Application Note

The role of autophagy is of particular interest in the study of neuronal cells, where it helps to maintain protein structure and function over long axonal distances.

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Image-Based Analysis of a Human Neurosphere Stem Cell Model for the Evaluation of Potential Neurotoxicants
Application Note

Here we demonstrate a 3D neurosphere model, composed of hNSCs, to conduct toxicity testing of several potential neurotoxicants.

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Detection of RNA in the central and peripheral nervous system using the RNAscope® in situ hybridization assay
Application Note

The RNAscope® in situ hybridization (ISH) assay provides a powerful method to detect gene expression within the spatial and morphological tissue context.

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