A Highly Robust and Sensitive Workflow for Quantifying RTP004 in Rat Serum

A Highly Robust and Sensitive SPE-LC-HRMS Workflow for Quantifying KR Rich Peptide RTP004 in Rat Serum RTP004 is a proprietary peptide used by Revance Therapeutics as a novel excipient in DaxibotulinumtoxinA for injection. Due to its high molecular weight, high isoelectric point and strong non-specific binding property, the sample preparation and LC-MS method development for this peptide is very challenging. Download this app note to discover how a SPE-LC-HRMS workflow: Enabled accurate quantitation of RTP004 in rat serum Provides high sensitivity, resolution, mass accuracy and robustness of large peptides Can easily be applied to other large peptides with low fragmentation efficiency