A Novel, Highly Selective Phosphopeptide Enrichment for Identification and Localization

Phosphopeptide enrichment is one of the most challenging sample preparation steps for LC/MS analysis due to the variation in reproducibility and selectivity caused by manual sample preparation.

The LC/MS analysis of the resulting phosphopeptide samples can be made difficult, due to factors such as suppression of phosphopeptide peaks and reduced ionization efficiency.

In this app note, discover a workflow solution for phosphopeptide enrichment that is:

• Fully automated
• Highly selective
• Reproducible