A Novel Lipid Screening Platform that Provides a Complete Solution for Lipidomics Research

 A major challenge in lipid analysis is the many isobaric interferences present in highly complex samples that confound identification and accurate quantitation. This problem, coupled with complicated sample preparation techniques and data analysis, highlights the need for a complete solution that addresses these difficulties and provides a simplified method for analysis. A novel lipidomics platform was developed that includes simplified sample preparation, automated methods, and streamlined data processing techniques that enable facile, quantitative lipid analysis. Herein, serum samples were analyzed quantitatively using a unique internal standard labeling protocol, a novel selectivity tool (differential mobility spectrometry; DMS) and novel lipid data analysis software.