Alcohol Withdrawal can be Deadly – Here's Why
Alcohol damages the brain, heart, liver and pancreas, and it increases the risk of some cancers, such as mouth and bowel cancer. It also weakens the immune system, making people more vulnerable to infectious diseases, such as pneumonia and tuberculosis. Taken in excess, it can kill.
Given these significant health consequences, it’s not surprising that many people who are addicted to the substance, try to quit. However, if it’s not done properly, withdrawal from alcohol can have terrible health consequences of its own, including death.
The body adapts to long-term change in order to survive. An example of this is angina, where the vessels supplying the heart with blood become narrow. Evidence suggests that people with the condition can slowly improve and adapt to the reduced blood flow by developing new blood vessels.
Similarly, there are physiological changes as a result of long-term alcohol abuse.
Alcohol suppresses the production of certain neurotransmitters (chemicals that carry messages between nerve cells). After a while, the body adjust to the continual presence of high amounts of alcohol by producing more of these neurotransmitters and their receptors – the proteins on the surface of nerve cells that neurotransmitters latch on to.
When people who are dependent on alcohol suddenly quit drinking, there is a surge in neurotransmitters, way above what the body needs. This surge explains many of the symptoms of sudden withdrawal, including sweating, racing heart, restlessness and feelings of anxiety.
The sudden removal of alcohol can cause fatal arrhythmias, where the heartbeat becomes so irregular the heart fails. This complicated biological process is due to the fact that alcohol interferes with the balance of GABA (an inhibitory neurotransmitter) and glutamate (an excitatory neurotransmitter).
The excitatory and inhibitory pathways in the brain control the central nervous system and heart. Once alcohol is removed, the huge levels of neurotransmitters that are present can overstimulate organs, including the heart.
This is often made worse by the fact that the heart’s structure changes with long-term alcohol use. Muscle strength and thickness, for example, are significantly reduced in people who consume more than 90g of alcohol per day (one unit of alcohol is equal to 8g of pure alcohol) over a period of five years or more.
The sudden removal of alcohol can also cause kidney failure. Alcohol has to be broken down and cleared from the body as urine. This needs water, as the products of the breakdown have to be in solution.
Alcohol also inhibits the production of an anti-diuretic hormone, so large quantities of alcohol make you urinate a lot and become dehydrated. Electrolytes in the body, such as sodium, magnesium, calcium and potassium, are usually in solution (water) and excessive amounts of alcohol can cause an imbalance in these electrolytes as well as an acid-base imbalance. These imbalances can eventually lead to acute kidney failure.
The risk of dying from sudden alcohol withdrawal are very real and very high, with estimates ranging from 6% to 25%, depending on their symptoms. Sadly, the unpleasant experience of withdrawal – both physical and mental – causes many addicts to relapse to heavy drinking.
If you drink alcohol, it is advisable that you stick to the government guidelines of not drinking more than 14 units of alcohol a week, which equates to about six pints of lager or six glasses of wine (175ml).
How does the gut talk to the brain? In this new case study from ProteinSimple, we find out how Melanie Maya Kaelberer, a Postdoctoral Associate at Duke University, is using Single-Cell Western platform Milo to answer the question of how the gut can rapidly communicate with cranial nerves.READ MORE
Chronic pain is a multifaceted disorder that causes profound disability worldwide. It has long been known that psychological stress contributes to adverse chronic pain outcomes in patients, but it is unclear how this is initiated or amplified by stress. Now, researchers have published results showing that activation of microglia in the mouse spinal cord is responsible for increased pain sensitivity in response to stress.READ MORE
The reproducibility crisis is holding back science. London-based Labstep, a start-up out of Oxford University, think that their tool can help make science more open and reproducible. That claim has now been given some concrete evidence with the announcement that the research contingent of the MRC Unit The Gambia at LSHTM will be trialling Labstep across their Banjul-based facility.READ MORE
14th Annual Conference on Dementia and Alzheimer's Disease
Sep 19 - Sep 20, 2019