Compound Management in the High-Throughput Era
Blog Oct 14, 2013
Compound management is as important as ever, and getting the right software for the job is essential. David Booth, Regional Sales Manager (Europe) for Titian Software speaks to us about the latest addition to Mosaic Software family, which is aimed at tackling just this sort of task.
TN: Can you tell us about the Mosaic Software and its primary applications?
DB: Mosaic provides a mechanism to manage sample inventories, but more significantly, it provides web-based requesting of samples, and the samples are prepared using a tracked workflow. In addition, Mosaic directly interfaces with a number of automated storage and dispensing systems so requestors receive precisely what they want, in a consistent and timely manner. The software is used in a broad range of organisations, including those with small collections right through to multiple site global inventories. Mosaic has become the leading management software for pharma R&D compound collections, and as it performs equally well with biologics and reagents, we now have increasing interest and use in other areas such as antibodies and siRNA collections.
TN: How important is compound management and how is this evolving?
DB: Very often the quantity of a compound generated - at high cost - can be very low, so the use of the sample needs to be carefully managed. More importantly it is vital to be certain of the identity, content and quality of a sample that is used in parallel assays. Mis-identifying a hit compound would be disastrous. With pharma’s new partnerships with CRO companies, the compounds are physically transferred to the CRO inventory. Having Mosaic within these CROs provides extra assurance to the pharma/biotech companies that the samples are being correctly tracked and handled.
TN: What are the major benefits associated with utilizing Titian’s Mosaic software?
DB: We provide a comprehensive solution that can cost-effectively support the needs of an organisation, with long-term product support. Mosaic easily supports a company’s stock management and distribution strategies for compounds, reagents and biologicals, and provides a flexible requesting mechanism so that users – wherever they are - can easily request samples in their preferred formats, ready for use. We can enhance the power of the automated stores and instruments and deliver samples consistently, saving time and effort. Mosaic’s recent support for Assay Requesting means that the assay runs can be efficiently batched together, saving expensive reagents and valuable screening platform time, as well as providing a convenient requesting and tracking interface for the users.
TN: How is laboratory automation transforming the way scientists work and achieve results?
DB: Automation brings enhanced capacity and consistency to science. It opens up techniques that simply cannot be performed manually, and this results in more accuracy, reduced costs and quicker, more definitive answers. In order to make best use of automation the surrounding processes sometimes have to be adapted. Mosaic manages the automated tasks and the related workflows, controlling the automation to deliver precisely what is required.
TN: What advice would you give to scientists looking to invest in high-throughput technology?
DB: Choosing a high throughput technology requires a sophisticated analysis of needs and benefits against investment. Once you have done this analysis on the technology, stand back and take a good look at the overall context of that technology – how can it be integrated? What other supporting processes need to change? And how will you ‘Feed the Beast?!’