Imaging Parkinson's Disease

In Parkinson's disease (PD) patients, certain MHC alleles have been found to be more prevalent than others. Researchers are now looking into whether PD is associated with an antigen-specific T cell response to α-Synuclein, a hallmark PD protein that aggregates and forms Lewy Bodies. It is now possible for α-Synuclein in the cerebrospinal fluid to be captured by antigen presenting cells and displayed by PD-associated MHC alleles, promoting adaptive immune responses.
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