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Molecular Target Identified to Treat Epilepsy in Autism
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Molecular Target Identified to Treat Epilepsy in Autism

Autism affects about 2% of children in the United States, and about 30% of these children have seizures. A new study has pointed towards the molecular cause of some of these seizures and potential treatments.
Why Does Protein Production Slow in This Peripheral Nerve Disease?
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Why Does Protein Production Slow in This Peripheral Nerve Disease?

A team has figured out why protein production slows down in the nerve cells of people suffering from Charcot-Marie-Tooth disease. This discovery could lead to a new therapeutic approach.
"Blood-to-Brain" Pathway Identified in Beginnings of Alzheimer's Disease
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"Blood-to-Brain" Pathway Identified in Beginnings of Alzheimer's Disease

Ground-breaking new research has discovered a possible new pathway that may kickstart Alzheimer’s disease, in a significant finding that offers potential new prevention and treatment opportunities.
Stem Cell Models Shows Role of Cholesterol in Alzheimer's Disease
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Stem Cell Models Shows Role of Cholesterol in Alzheimer's Disease

New research has found elevated cholesterol supply from astrocytes to neurons in the model of Alzheimer's disease (AD) brains, suggesting that modulating brain cholesterol could be explored in the search of treatment options for the devastating, degenerative disease.
The Brain Overcomes Uncertainty To Plan Motor Actions
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The Brain Overcomes Uncertainty To Plan Motor Actions

In baseball, batters have roughly 50 milliseconds to decide whether to swing. Despite this short window, batters still manage to hit the ball roughly 25 percent of the time. The mechanisms underlying these feats are at the center of new research.
Protein Could Be a Central Target for Treating Dementia
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Protein Could Be a Central Target for Treating Dementia

In a study published this month in Communications Biology, researchers from Tokyo Medical and Dental University (TMDU) have revealed that the protein HMGB1 is a key player in both frontotemporal lobar degeneration and Alzheimer disease, two of the most common causes of dementia.
Antioxidant Fails To Slow Parkinson’s Disease Progression in Clinical Trial
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Antioxidant Fails To Slow Parkinson’s Disease Progression in Clinical Trial

The hypothesis that raising the brain levels of the natural antioxidant urate could slow the progression of Parkinson’s disease (PD) has been disproven by researchers at Massachusetts General Hospital (MGH).
Targeting Biotin-Dependent Metabolism To Treat Glioblastoma
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Targeting Biotin-Dependent Metabolism To Treat Glioblastoma

Glioblastoma's dependency on biotin distribution suggests that biotin-dependent metabolism and epigenetic pathways could be targeted therapeutically to treat the disease.
90% of Patients With Alzheimer's Disease Would Not Have Qualified for Aducanumab Trials
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90% of Patients With Alzheimer's Disease Would Not Have Qualified for Aducanumab Trials

In June 2021, the Food & Drug Administration (FDA) granted accelerated approval for aducanumab to treat patients with mild cognitive impairment or mild dementia due to Alzheimer’s disease. A new study has shown that the vast majority of Medicare enrollees with these diagnoses would have excluded been excluded from the aducanumab clinical trials, raising questions about side effects of the drug in vulnerable populations.
A New Antibody Therapy for Muscular Dystrophy
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A New Antibody Therapy for Muscular Dystrophy

Northwestern Medicine scientists have developed an antibody that they believe can be used to treat muscular dystrophy, findings that were published in Science Translational Medicine.
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