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Fungal Infection Leads to Brain Inflammation and Memory Impairment
Fungal Infection Leads to Brain Inflammation and Memory Impairment
News   Jan 07, 2019

Researchers have developed a mouse model to study the short-term consequences of fungal infection in the brain. They have found that the common yeast Candida albicans can cross the blood-brain barrier and trigger an inflammatory response that results in the formation of granuloma-type structures and temporary mild memory impairments in mice.

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New Test Detects Protein Associated With Alzheimer's and CTE
New Test Detects Protein Associated With Alzheimer's and CTE
News   Jan 07, 2019

An ultrasensitive test has been developed that detects a corrupted protein associated with Alzheimer’s disease and chronic traumatic encephalopathy (CTE), a condition found in athletes, military veterans, and others with a history of repetitive brain trauma.

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Glucagon-producing Cells Forced to Produce Insulin: New Therapeutic Approach for Diabetes?
Glucagon-producing Cells Forced to Produce Insulin: New Therapeutic Approach for Diabetes?
News   Jan 07, 2019

Following beta cell loss in mice, 1-2% of glucagon-producing α-cells spontaneously engage in insulin production. In this study, this was increased to 5%, providing new insights on cell flexibility and opening up therapeutic approaches for diabetes and other diseases caused by cell death.

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Obsessive-Compulsive Symptoms in Youth: A Psychological Red Flag?
Obsessive-Compulsive Symptoms in Youth: A Psychological Red Flag?
News   Jan 07, 2019

Engaging in repetitive and ritualistic behaviors is part of typical child development. However, behaviors that develop into obsessive and compulsive symptoms (OCS) may represent a red flag for serious psychiatric conditions. Researchers found children and young adults with OCS who also admitted to having bad thoughts were more likely to also experience psychopathology.

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Gut Immune Cells Are Recruited to Fight Multiple Sclerosis
Gut Immune Cells Are Recruited to Fight Multiple Sclerosis
News   Jan 04, 2019

Researchers have discovered that the intestinal IgA-producing immune cells reduce brain inflammation in people with multiple sclerosis (MS), and that increasing the number of these cells blocks inflammation entirely in a preclinical model of the disease.

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Improved Treatment for Alcohol Use Disorders
Improved Treatment for Alcohol Use Disorders
News   Jan 04, 2019

Helping people with addictions has become a research passion for Purdue University researchers who is leading a team to make drug discoveries to support millions around the world dealing with alcohol use disorders, chronic pain and mood disorders. The team's recent discovery provides a new avenue for the development of medications that provide therapeutic relief for a patient without causing unwanted side effects.

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Seeing Double
Seeing Double
News   Jan 04, 2019

The visual system is probably the best understood part of the brain. Over the past 75 years, neuroscientists have assembled a detailed account of our brain processes visual data. But a new study is calling a fundamental aspect of vision science into question, showing that even the best-studied parts of the brain can still hold plenty of surprises.

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The Most Important Hair on Your Head is on the Inside
The Most Important Hair on Your Head is on the Inside
News   Jan 04, 2019

Cells along the brain's cavities are equipped with tiny hair-like protrusions called cilia. Cilia are still poorly understood, but people with ciliary defects can develop neurological conditions like hydrocephalus and scoliosis. New research now shows that cilia are essential for the brain to develop normally.

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Notch, Nestin and Neurons
Notch, Nestin and Neurons
News   Jan 04, 2019

In the developing brain, the 3 main cell types, specifically neurons, astrocytes and oligodendrocytes, are generated from neural stem cells.
Using mice deficient in nestin, a nanofilament protein, researchers have shown that nestin produced in astrocytes has an important role in inhibiting neuronal differentiation.

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Drinkable Cocktail of Drug Molecules to Treat Alzheimer’s
Drinkable Cocktail of Drug Molecules to Treat Alzheimer’s
News   Jan 03, 2019

Yale researchers have identified a drinkable cocktail of designer molecules that interferes with a crucial first step of Alzheimer’s and even restores memories in mice.

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