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Dorsal Rooth Ganglion Pathology Associated With AAV Gene Therapy in Animal Model
A meta-analysis of non-human primate (NHP) studies showed that adeno-associated virus (AAV) gene therapy often caused dorsal root ganglion (DRG) pathology. There were no clinical effects.
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A Peek Into the Black Box: How Do Neural Networks "Think"?
Face recognition, object detection, and person classification by machine learning algorithms are now in widespread use. However, machine learning is like a black box: computers take decisions they regard as valid but it is not understood why one decision is taken and not another. An new study has taken a peek into the black box of neural networks.
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Repulsing Neurons Help Create Columns in the Brain
The brain's structure has columnar features, which are hypothesized to arise from nerve cells stemming from the same parent cell, initially forming radial units. How exactly this process unfolds at the molecular level remains unexplained, however. Now, an important insight has been gleaned from a study of the fly brain.
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In Schizophrenia, Nature Trumps Nurture
UCI research led by Amal Alachkar found that too much of a certain amino acid in utero caused schizophrenia in mice despite the quality of postpartum caregiving – and the study suggests that the same would be true with humans.
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The Body's Waste Removal System Syncs With Circadian Rhythms
New research details how the complex set of molecular and fluid dynamics that comprise the glymphatic system – the brain's unique process of waste removal – are synchronized with the master internal clock that regulates the sleep-wake cycle.
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How Has the COVID-19 Pandemic Affected People With Progressive Multiple Sclerosis?
Researchers conducting a large international study of progressive multiple sclerosis (MS) examined the impact of the global outbreak of coronavirus disease 2019 (COVID-19) on their study participants.
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Holistic Bursting Cells Could Be Basis of Brain Cognition
Researchers have announced the discovery of "holistic bursting" cells, a novel functional class of cortical neurons that represent learned complex objects as wholes rather than parts.
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Is Consciousness Continuous or Discrete? It Could Be Both, Suggests New Theory
Two major theories have fueled a now 1,500 year-long debate started by Saint Augustine: Is consciousness continuous, where we are conscious at each single point in time, or is it discrete, where we are conscious only at certain moments of time?
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Kidney Problems May Lead to Cognitive Problems in Midlife
If you have moderate-to-high risk of kidney failure as a young adult, you may be at risk for worse cognitive function in middle age, a new study suggests.
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Using Magnetic Resonance Elastography to Detect Epilepsy
A new study from the Beckman Institute used magnetic resonance elastography to compare the hippocampal stiffness in healthy individuals with those who have epilepsy.
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