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Psychedelic Drug MDMA May Reawaken ‘Critical Period’ in Brain to Help Treat PTSD
Johns Hopkins scientists have used MDMA to reopen a “critical period,” when the brain is sensitive to learning the reward value of social behaviors.
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Blocking Protein’s Activity Restores Cognition in Old Mice
Brain cells called microglia serve as the brain’s garbage crew, scarfing up bits of cellular debris. But their underperformance in aging brains contributes to neurodegeneration. Could a strategy to restore this homeostasis be on the horizon?
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Largest Study of Its Kind Identifies New Genetic Causes of Poor Sleep
A research study has found 47 links between our genetic code and the quality, quantity and timing of how we sleep. They include ten new genetic links with sleep duration and 26 with sleep quality.
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Anti-inflammatory Drugs Prove Ineffective for Alzheimer's Prevention
Based on studies that showed that “super-aspirins” or Nonsteroidal anti-inflammatory drugs (NSAID) could help avoid Alzheimer's, researchers at developed a new approach to AD prevention trials, and used it to test whether the common NSAID naproxen could indeed stop the disease in its tracks, before people developed AD symptoms. Sadly, the results were not encouraging.
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Body Clock-related Alterations in Cognition Important for Heart Failure
This study reveals how cognition and mood in mice are regulated by the body clock and how pertinent brain regions are impaired in heart failure.
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Just How Good Are Protein Disorder Prediction Programs?
Proteins with disordered regions may also be sticky, and clump together inside and between cells, and are directly implicated in a number of neurodegenerative diseases. Thus, being able to identify disordered regions in proteins is highly important. Researchers have generated and validated a representative experimental benchmarking set of site-specific and continuous disorders, using deposited NMR chemical shift data for more than a hundred selected proteins.
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"Out of Body Experience" Illusion Finds Differences in People With Autism
New research has indicated that people with autism have an altered sense of self, which may explain some of the differences shown in social functioning. It is the first time that responses to the self-altering ‘full body illusion’, which simulates an out of body experience, have been measured in people with autism.
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Is Skyrmionics the Future of Data Storage?
Scientists at the Universities of Birmingham, Bristol and Colorado Boulder have moved a step closer to developing the next generation of data storage and processing devices, using an emerging science called skyrmionics.
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Treating Depression, Obesity and Chronic Pain by Targeting One Protein
Major depression, obesity and chronic pain are all linked to the effects of one protein, called “FK506-binding protein 51,” or FKBP51. Now a research group has developed a highly selective compound that can effectively block FKBP51 in mice, relieving chronic pain and having positive effects on diet-induced obesity and mood. The new compound also could have applications in alcoholism and brain cancer.
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PET Biomarker Predicts Alzheimer's Progression
Researchers have discovered a way to better predict progression of Alzheimer's disease. By imaging microglial activation levels with positron emission tomography (PET), researchers were able to better predict progression of the disease than with beta-amyloid PET imaging, according to a study published in the April issue of the Journal of Nuclear Medicine.
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