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A team of neuroscientists led by Florida Atlantic University’s Brain Institute sought to answer a fundamental question in their quest to combat Alzheimer’s disease — “Is amyloid precursor protein the mastermind behind Alzheimer’s disease or is it just an accomplice?”

Zebrafish, in contrast to humans, have outstanding regenerative capacities: and can regrow brain cells from so-called progenitor cells. Scientists have now determined that these progenitor cells consist of eight different sub-populations. In a fish model of Alzheimer’s disease, only some of these populations increased proliferation to restore lost cells.

Our actions are driven by "internal states" such as anxiety, stress or thirst. Not much is known about how such states are represented by complex brain-wide circuits, including sub-cortical structures such as the amygdala. A new study has used a deep brain imaging technique to monitor amygdala activity in mice and revealed the neuronal dynamics encoding behavioral states.

A new study confirms that a simple blood test can reveal whether there is accelerating nerve cell damage in the brain. The researchers analyzed neurofilament light protein in blood samples from patients with Alzheimer’s disease.

Progress in understanding the genetic mutation responsible for Huntington's disease (HD) and at least some molecular underpinnings of the disease has resulted in a new era of clinical testing of potential treatments. A new survey of HD patients has provided valuable information for clinical trial design.

Researchers using sophisticated MRI technology have found that higher levels of body fat are associated with differences in the brain's form and structure, including smaller volumes of gray matter. The findings add important information to our understanding of the connection between obesity and negative health consequences such as dementia.

UA researchers are developing a tool to calculate the likelihood of traumatic brain injury after a vehicle collision, using an approach that fuses experimental and computational data.

When a protein named "Merlin" fails to do its job, people can develop slow-growing, life-disrupting auditory nerve tumors that can disrupt their hearing and balance. Now scientists at Cincinnati Children's have discovered much more about how Merlin does its job – by working behind the scenes through a network of more than 50 other proteins.

The work points to the existence of a grid-like hexagonal structure in olfactory-related brain areas, similar to mapping configurations previously found to support spatial navigation in animals.

Incremental physical activity, even at light intensity, is associated with larger brain volume and healthy brain aging.