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Investigational Drug Interferes with Mechanisms Linked to Alzheimer's Disease
The chemical compound "anle138b" eases cognitive deficits and normalizes gene expression in a mouse model of Alzheimer's disease. Furthermore, the drug seems to close harmful openings in the membrane of nerve cells. An international collaboration reports these findings in the journal EMBO Molecular Medicine. The scientists suggest that anle138b should be validated in clinical trials for its potential to treat Alzheimer's and possibly other neurodegenerative diseases.
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Two Areas of the Same Brain Region Control Moderate Vs Compulsive Cocaine Intake
The research explains how an imbalance in the activity of different populations of brain cells can increase the urge to take drugs.
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Aged Rhesus Macacque Monkey Brains Show Similar Alzheimer's Pathology to Humans
Very old rhesus monkeys exhibit similar patterns of brain pathology as human Alzheimer’s patients.
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'Brain-on-a-Chip' Tests Effects of Biological and Chemical Agents
Lawrence Livermore National Laboratory scientists and engineers have developed a “brain-on-a-chip” device aimed at testing and predicting the effects of biological and chemical agents, disease or pharmaceutical drugs on the brain over time without the need for human or animal subjects.
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Your Mood Depends on the Food You Eat
The cross-sectional study also found that what you eat should eat to improve your mental health changes as you get older.
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Nanodiscs Catch Misfolding Proteins Red-Handed
When proteins misfold, accumulate and clump around insulin-producing cells in the pancreas, they kill cells. Now, researchers have obtained a structural snapshot of these proteins when they are most toxic, detailing them down to the atomic level.
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Children With Congenital Zika Virus Infection Face Serious Challenges as They Age
The report from the CDC is the first to describe the health and developmental effects of congenital Zika virus infection in children with microcephaly through 2 years of age.
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Anti-Stress Compound Reduces Obesity and Diabetes
Researchers find a stress protein found in muscle has a diabetes promoting effect
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Inflammation Causes Chemo Brain
The research could lead to a new practice of identifying inflammatory biomarkers in cancer patients and then treating the inflammation with medications or exercise to improve cognition and other symptoms.
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Scientists Probe Genetics of Long and Short Sleepers
Scientists have identified differences in a group of genes they say might help explain why some people need a lot more sleep - and others less - than most.
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