We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience, read our Cookie Policy

Advertisement

Activation Sequence of the SARS-CoV-2 Spike Protein Unveiled

News   May 05, 2020 | Original story from the German Primate Center

 
Activation Sequence of the SARS-CoV-2 Spike Protein Unveiled

(A) Schematic representation of SARS-CoV-2, the viral spike protein and the cleavage sites for furin (green, S1/S2 position; the cleavage sequence is shown below the protein structure) and TMPRSS2 (orange, S2' position). (B) First, in already infected cells, the enzyme furin cuts the spike protein at the S1/S2 site. The spike protein then mediates viral attachment to a new host cell. In order to efficiently enter the cell, the spike protein still needs to be activated by the enzyme TMPRSS2. Activation by TMPRSS2 is only possible if the spike protein has previously been cleaved by furin. Credit: Markus Hoffmann

 
 
Advertisement
 

RELATED ARTICLES

Greenland Melting May Be Expedited by Sedimentary Bacteria

News

Bacteria are likely triggering greater melting on the Greenland ice sheet, possibly increasing the island’s contribution to sea-level rise, according to scientists.

READ MORE

Details of Virus Reproduction Revealed by Physics

News

The reproductive cycle of viruses requires self-assembly, maturation of virus particles and, after infection, the release of genetic material into a host cell. New physics-based technologies allow scientists to study the dynamics of this cycle and may eventually lead to new treatments.

READ MORE

Exploiting the Antimicrobial Properties of Toadlet Peptide To Kill Bacteria

News

Researchers have uncovered specific molecular properties of an antimicrobial peptide from the skin of the Australian toadlet that could be exploited in efforts to develop novel synthetic drugs to combat bacterial infections.

READ MORE

 

Like what you just read? You can find similar content on the communities below.

Proteomics & Metabolomics Immunology & Microbiology

To personalize the content you see on Technology Networks homepage, Log In or Subscribe for Free

LOGIN SUBSCRIBE FOR FREE