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Alcohol exposure during pregnancy affects multiple generations
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Alcohol exposure during pregnancy affects multiple generations

Alcohol exposure during pregnancy affects multiple generations
News

Alcohol exposure during pregnancy affects multiple generations

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When a mother drinks alcohol during pregnancy, even a small dose, she can increase the chances that the next three generations may develop alcoholism, according to a new study from Binghamton University.


A research team led by Nicole Cameron, assistant professor of psychology at Binghamton University, was the first to investigate the effects of alcohol consumption during pregnancy on alcohol-related behavior (consumption and sensitivity to the effect of alcohol) on generations that were not directly exposed to alcohol in the uterus during the pregnancy.


See Also: Prenatal alcohol exposure alters development of brain function


In the study, pregnant rats received the equivalent of one glass of wine, four days in a row, at gestational days 17-20, the equivalent of the second trimester in humans. Juvenile male and female offspring were then tested for water or alcohol consumption. Adolescent males were tested for sensitivity to alcohol by injecting them with a high-alcohol dose, which made them unresponsive (drunk on their back), and measuring the time it took them to recover their senses (back on their four paws). The results suggest that if a mother drinks during pregnancy, even just a little bit, she increases the risk that her progeny will become alcoholic.


Ethanol intake across 3 generations. Credit: Nicole Cameron, Binghamton University / Alcoholism: Clinical and Experimental Research, 2016
 


"Our findings show that in the rat, when a mother consumes the equivalent of one glass of wine four times during the pregnancy, her offspring and grand-offspring, up to the third generation, show increased alcohol preference and less sensitivity to alcohol," said Cameron. "Thus, the offspring are more likely to develop alcoholism. This paper is the first to demonstrate trans-generational effects of alcohol consumption during pregnancy on alcohol-related behavior in offspring."


Learn More: Can drinking alcohol harm the child before the mother knows she is pregnant?


To date, no study has shown a transgenerational effect of prenatal ethanol exposure on ethanol consumption in the second or third generation. Other research investigated the effects of alcohol exposure during pregnancy studied the effects only on the fetuses directly exposed or the effects on cellular activity over multiple generations, but never alcohol-related behaviors over multiple generations.


Cameron and her team recently received a National Institute on Alcohol Abuse and Alcoholism grant to continue the research on the transgenerational effects of gestational alcohol exposure.


"We now need to identify how this effect is pass through multiple generations by investigating the effects alcohol has on the genome and epigenome (molecules that control gene translation)," said Cameron.


Note: Material may have been edited for length and content. For further information, please contact the cited source.

Binghampton University   press release


Publication

Nizhnikov ME, Popoola DO, Cameron NM. Transgenerational Transmission of the Effect of Gestational Ethanol Exposure on Ethanol Use-Related Behavior.  Alcoholism: Clinical and Experimental Research, Published Online February 15 2016. doi: 10.1111/acer.12978


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