ALS Protein's Path into the Brain Documented
Neuronal cell line showing Angiogenin (green) in the nucleus and in the neurite outgrowths. Credit: University of Bath
University of Bath scientists have developed a better understanding of a key protein associated with brain diseases including ALS (motor neurone disease) and dementia by studying how it enters central nervous system cells.
Researchers from the Department of Biology & Biochemistry studied how angiogenin, a protein which crosses into cells and is transported to the cell nucleus, works.
The protein has important roles in developing and protecting healthy brains and growing blood vessels, but mutated angiogenin is linked to the brain disease Amyotrophic Lateral Sclerosis (ALS), also known as motor neurone disease or Lou Gehrig’s disease, as well as a type of dementia called Fronto-temporal dementia (FTD).
Recently, angiogenin has also been shown to play an important role in the regeneration of blood stem cells
In a series of in vitro experiments the researchers tested how normal angiogenin was taken into several types of central nervous system cells, under a variety of different biochemical conditions to discover the route it was taking into the cells.
Their key finding is that angiogenin uptake into these cells seems to have more than one biochemical pathway, a finding which means the overall picture of how angiogenin functions is even more complicated than previously suspected.
Dr Vasanta Subramanian, from the Department of Biology & Biochemistry, who led the research, said: “Ultimately understanding the precise function of this protein is really important, and understanding how cells take it up is a critical part of that.
“We discovered that angiogenin is taken up into cells by more than one mechanism which is quite a surprise. It means that coming to a full understanding of how it really works is not going to be so easy, but the more we know about this protein the better because it’s involved in several really crucial biological processes.”
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Comments | 1 ADD COMMENT
Sorice Madina | Mar 08, 2018
My mother was diagnosed with ALS in May 2008. Her doctor put her on riluzole, letting her know there was no cure but the medication might provide her a few more months of delayed symptoms. ALS progresses at different rates and affects different body parts first. My mother, being 73 at the time, fell into a category of what they call "fast progression" (older female). Her arms weakened first, then her hands, her mouth, and throat, and finally her lungs. Throughout her two-and-a-half-year ordeal, she was able to walk with assistance. All the while she continued to take the riluzole. If it bought my mother any time, we will never know. Her neurologist told us that if she couldn't afford it, there was no real need to take it. She lost touch with reality. Suspecting it was the medication I took her off the riluzole (with the doctor’s knowledge) and started her on the ALS natural herbal formula we ordered from GREEN HOUSE HERBAL CLINIC, We spoke to few people who used the treatment here in Canada and they all gave a positive response, her symptoms totally declined over a 7 weeks use of the Green House ALS disease natural herbal formula. She is now almost 83 and doing very well, the disease is totally reversed! (Visit their website www . Greenhouseherbalclinic . com) I am thankful to nature, herbs are truly gift from God. Share with friends!!
10th International Conference on Mass Spectrometry and Chromatography
Oct 08 - Oct 09, 2018