We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.


Altered brain communication could be predictive marker of dementia in Parkinson's disease

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "Altered brain communication could be predictive marker of dementia in Parkinson's disease"

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

Read time:

Dementia will develop in about 80% of patients with Parkinson's disease, and a new study has found significant variability in brain signaling that could serve as a predictive marker for identifying which patients are at highest risk of dementia. Measuring brain signal variability as an early indicator of impaired cognitive function and information processing is an innovative new approach described in the study published in Brain Connectivity.

See Also: Being underweight in middle age associated with increased dementia risk

In the paper, J.A. Bertrand and coauthors from Baycrest Center (Toronto), Hôpital du Sacré-Cœur de Montréal, McGill University (Montreal), Université de Montréal, Centre Hospitalier de l'Université de Montréal, and Universiteé du Québec à Montréal, Canada, describe the use of resting state electroencephalography (EEG) for a mean of 3 years in patients with Parkinson's disease, comparing the findings in those in whom dementia did or did not develop. The researchers measured specific disruptions in brain communication that were present before symptoms of dementia were apparent. If confirmed by additional studies, these brain signaling alterations could identify the best patients to include in trials of new neuroprotective drugs.

Learn More: Three-minute test detects common form of dementia that's hard to diagnose

“Early diagnosis is key to treatment of dementia patients with the limited options currently available,” says Christopher Pawela, PhD, Co-Editor-in-Chief of Brain Connectivity and Assistant Professor, Medical College of Wisconsin. “EEG is a lower-cost alternative to many modern diagnostic imaging modalities. If a reliable predictive marker for dementia could be developed using EEG, it may find lower barriers to clinical use.” 

Note: Material may have been edited for length and content. For further information, please contact the cited source.

Mary Ann Liebert, Inc. Publishers   press release


Bertrand J-A et al. Brain Connectivity Alterations Are Associated with the Development of Dementia in Parkinson's Disease.  Brain Connectivity, Published March 31 2016. doi: 10.1089/brain.2015.0390