BioFocus DPI Enhances ADME/PK Laboratory Bioanalytical Capabilities
News Feb 27, 2009
BioFocus DPI has announced that it has strengthened its ADME/PK Laboratory bioanalytical capabilities through the installation of a Waters® Xevo™ TQ Mass Spectrometer. As one of the first European-based CROs to use this instrument, ADME/PK Laboratory enhances its ability to identify drug metabolites for customers.
The use of the Xevo™ TQ-MS combined with Waters UltraPerformance LC® (UPLC) technology increases BioFocus DPI ADME/PK Laboratory’s throughput and allows accurate measurements to both quantify and confirm the identity of metabolites in a wide range of biological fluids and tissues.
For molecules that would have a poor response using standard technologies, the Xevo™ TQ-MS will increase the likelihood of detection. In addition to bioanalysis, ADME/PK Laboratory offers high-quality services backed by expert consultancy - extending from discovery ADME to in vivo pharmacokinetics.
“We are building ADME/PK Laboratory’s advanced bioanalysis service to provide the best ADME data to support drug discovery programs for our UK, US and European clients,” said Chris Newton, SVP BioFocus DPI. “With this newly installed instrument providing greater sensitivity, accuracy and speed, we further enhance the service that we deliver - whether this is for a small scale study or as part of an integrated drug discovery program.”
Chinese researchers have developed interfacially polymerized porous polymer particles for low- abundance glycopeptide separation. These polymer particles - with hydrophilic-hydrophobic heterostructured nanopores - can separate low-abundance glycopeptides from complex biological samples with high-abundance background molecules efficiently.