Bioo Scientific Corp. Receives NIH Grant for the Development of Novel Anti-Viral Therapeutics
News May 05, 2009
When a virus uncoats its genome after it infects a cell, the cell theoretically has a golden opportunity to attack the unprotected genome before it starts the process of making viral-specific products that cause problems in the cell.
Researchers at Colorado State University have recently discovered a mechanism by which several viruses specifically suppress aspects of the cell in order to stabilize their nucleic acids to promote an efficient infection. This finding has revealed a prospective 'Achilles' heel' for viruses that has significant therapeutic potential.
In a partnership with Colorado State and the Rocky Mountain Regional Center of Excellence in Biodefense and Emerging Diseases, Bioo Scientific recently received a $1.25 million, 5 year grant award to develop novel methodologies and compounds that will specifically overcome this viral suppression mechanism and allow cells to effectively attack viral nucleic acids.
“We are pleased to be able to contribute our expertise in drug discovery and development to this project” said Dr. Lance Ford, Bioo’s VP for Research and Development.
“We are also very much looking forward to working with the cadre of biodefense-oriented microbiologists in the Rocky Mountain region. One aspect of the project that we find particularly exciting is that the treatments we will be developing could then be used to treat infections with multiple viruses of biodefense significance. Theoretically, the therapeutics could even be effective against rapidly evolving viruses like influenza,” Dr. Ford continued.
Computation and Chemistry Combine to Create World-First Auxetic ProteinNews
A team of chemists at the University of California, San Diego (UCSD) has now designed a two-dimensional protein crystal that toggles between states of varying porosity and density. This is a first in biomolecular design that combined experimental studies with computation done on supercomputers. The research, published in April 2018 in Nature Chemistry, could help create new materials for renewable energy, medicine, water purification, and more.
Fructose Formula Poses Risk to Babies With Metabolic DisorderNews
Babies with inherited intolerance of fructose face a risk of acute liver failure if they are fed certain widely available formulas containing fructose, pediatricians and geneticists are warning. Baby formula manufacturers should remove fructose or sucrose, or explicitly label their products to allow parents to avoid those sweeteners if necessary, the doctors say.
4000-Year Old DNA Helps Track the Spread of Rice Farming in AsiaNews
Rice farming spread far and wide in ancient Southeast Asia, but how it got there has been a mystery. Now, a study of 4000-year-old DNA—a rare find in this region—suggests it came with farmers migrating from China, where rice farming originated.