Bird and Turtle Chromosomes Help Identify Dinosaur DNA
News May 22, 2018 | Original Press Release from the University of Kent
The chromosomes of turtles, like the Spiny Softshell Turtle (pictured) have helped researchers trace the structure of dinosaur DNA. Credit: University of Kent
By comparing the genomes of different species, chiefly birds and turtles, the Kent team were able to determine how the overall genome structure (i.e. the chromosomes) of many people’s favourite dinosaur species – like Velociraptor or Tyrannosaurus – might have looked through a microscope.
The research was carried out in the laboratory of Professor Darren Griffin, of the University’s School of Biosciences, and is now published in the journal Nature Communications. It involved extrapolating the likely genome structure of a shared common ancestor of birds and turtles that lived around 260 million years ago – 20 million years before the dinosaurs first emerged.
Dr Becky O’Connor, senior postdoctoral researcher and co-author of the Nature Communications paper, then traced how chromosomes changed over evolutionary time from a reptile ancestor to the present day.
The team found that, although the individual chromosomes rearranged their genes internally, this did not occur much at all between the chromosomes – what the scientists describe as ‘a significant discovery’.
Birds (which are themselves living dinosaurs) have a lot of chromosomes compared to most other species and that is possibly one of the reasons why they are so diverse. This research suggests that the pattern of chromosomes (karyotype) seen in early emerging dinosaurs and later theropods is similar to that of most birds and, again, may help explain their great diversity.
The new discovery suggests that, had scientists had the opportunity to make a chromosome preparation from a theropod dinosaur, it might have looked very similar to that of a modern-day ostrich, duck or chicken.
One of the key pieces of biotechnology that made it possible was the development of a set of fluorescent probes derived from birds that worked well on the chromosomes of turtles.
This article has been republished from materials provided by the University of Kent. Note: material may have been edited for length and content. For further information, please contact the cited source.
Reference: O’Connor, R. E., Romanov, M. N., Kiazim, L. G., Barrett, P. M., Farré, M., Damas, J., … Griffin, D. K. (2018). Reconstruction of the diapsid ancestral genome permits chromosome evolution tracing in avian and non-avian dinosaurs. Nature Communications, 9(1), 1883. https://doi.org/10.1038/s41467-018-04267-9
As genome editing technologies advance toward clinical therapies, they are raising hopes of a completely new way to treat disease. However, challenges need to be addressed before potential treatments can be widely used in patients. To tackle these challenges, the National Institutes of Health has launched the Somatic Cell Genome Editing program, which has awarded multiple grants including more than $3.6 million to assess the safety of genome editing in human cells and tissues.