We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Can Brain Stimulation Cut Excessive Drug Use in Schizophrenia?

Can Brain Stimulation Cut Excessive Drug Use in Schizophrenia?

Can Brain Stimulation Cut Excessive Drug Use in Schizophrenia?

Can Brain Stimulation Cut Excessive Drug Use in Schizophrenia?

Credit: Ermal Tahiri/ Pixabay
Read time:

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "Can Brain Stimulation Cut Excessive Drug Use in Schizophrenia?"

First Name*
Last Name*
Email Address*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

Repetitive transcranial magnetic stimulation (rTMS) was associated with a reduction in self-reported cannabis use by up to 60 per cent among people with schizophrenia who have cannabis use disorder (CUD), according to a CAMH-led study just published in the journal NPJ Schizophrenia.

The double-blind study is the first of its kind to investigate the effectiveness of rTMS in treating CUD in people with schizophrenia, and was supported by the U.S. National Institute on Drug Abuse (NIDA) and the CAMH Foundation.

“People with schizophrenia have very high rates of cannabis use disorder compared to the general population, and there is strong evidence that cannabis use worsens psychiatric symptoms and quality of life in these people,” said senior author CAMH clinician scientist Dr. Tony George. “Despite the known harmful effects, there is currently no approved treatment for CUD with or without schizophrenia.  These results indicate rTMS may be a safe and effective way to reduce cannabis among people with schizophrenia.”

Until relatively recently, brain stimulation technologies like rTMS were used primarily for treatment-resistant depression. However, studies have now found rTMS to be effective in reducing drug use and cravings for several substance use disorders in the general population.

Study participants were given rTMS treatment at the Temerty Centre for Therapeutic Brain Intervention at CAMH five times a week for four weeks targeting the brain’s the dorsolateral prefrontal cortex (DLPFC), which is associated with the brain’s reward system and executive function. 

Those who were given rTMS reported a reduction in cannabis use by up to 60 per cent after 28 days as well as reduced cravings, compared to controls receiving sham rTMS.

The authors state that one of the reasons there is currently no effective treatment for CUD in people with schizophrenia is that people with schizophrenia or other mental illnesses are usually excluded from CUD clinical trials. Dr. George says that CAMH is uniquely positioned to do this kind of research:

“In addition to our ability to conduct clinical trials with brain stimulation at the Temerty Centre, CAMH also has one of the largest schizophrenia outpatient clinics in North America as well as state-of-the-art addiction treatment programs,” said Dr. George. “All those factors make CAMH one of the few places in the world that can lead a study like this.”

"It was a difficult study to recruit for given the intensity of time commitment required by patients,” said study lead author Dr. Karolina Kozak Bidzinski. “However, the awareness patients had of the negative effects cannabis was having on their lives, the expected benefits of reducing their use and noticing the various positive outcomes that would surface throughout the duration of the trial, enabled such a high number of patients to complete the study. Hopefully this work paves the way for more research into investigating the effects of rTMS as a treatment for cannabis use disorder in people with schizophrenia."

Reference:  Bidzinski KK, Lowe DJE, Sanches M, et al. Investigating repetitive transcranial magnetic stimulation on cannabis use and cognition in people with schizophrenia. NPJ Schizophr. 2022;8(1):1-11. doi: 10.1038/s41537-022-00210-6


This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.