Canadian Scientists Identify Chromosome Linked to Colorectal Cancer

Researchers at the Ontario Institute for Cancer Research and Cancer Care Ontario have identified a specific genetic variation on chromosome 8 that is associated with colorectal cancer. This is the first genetic predictor that has been identified for the most common forms of colorectal cancer to date and may play a significant role in how people are screened for the disease.

The study was published in Nature Genetics reporting the work of the Assessment of Risk for Colorectal Tumours in Canada (ARCTIC) project. The project involved researchers from around the world including the U.S., France, England and Scotland who analyzed more than 100,000 genetic elements from 10,000 people, including 2,400 Ontarians from the Ontario Familial Colorectal Cancer Registry.

Previous research on this chromosome has linked it to other forms of cancer, including prostate cancer, suggesting that individuals with this newly discovered variation may be at risk for a broad spectrum of cancers.

"This discovery will lead to better understanding of colorectal cancer biology and the cause of this disease," said Dr. Tom Hudson, co-principal investigator and president and scientific director of the Ontario Institute for Cancer Research. "This information can be used to identify those at risk of colorectal cancer and direct them to screening at an earlier age."

"This breakthrough could lead to new methods of testing for colorectal cancer," said Dr. Brent Zanke, co-principal investigator and scientist at Cancer Care Ontario. "For example, this genetic variation could be detected through a tool as simple as a blood test. Used as part of a screening program, this information could help individualize screening and prevention efforts saving lives and money."

Further studies may lead to the identification of additional common genetic risk predictors for colorectal cancer.