ChromaDex® and Scripps Research Institute Collaborate on METLIN Metabolite Database
News Jun 01, 2012
The Scripps METLIN Metabolite Database is a repository of metabolite information that includes tandem mass spectrometry data for over 55,000 unique and potentially therapeutic compounds. It is a public, web-based database designed for the archiving, visualization, and analysis of metabolite data. The information is provided to facilitate metabolomics experiments by providing scientists with a comprehensive source of structures for potential metabolites of their compounds of interest. An annotated list of known metabolites and their mass, chemical formula, and structure are available on the METLIN website. The METLIN database was developed and is maintained by the Siuzdak laboratory at the Scripps Research Institute, La Jolla, California.
Currently, there is limited information for natural products in the database. By expanding the population of data, it will increase the knowledge base and visibility for researchers to screen potential compounds for use in areas of clinical interest, such as cancer, heart disease, diabetes, or Alzheimer's.
"We are very excited about expanding the METLIN metabolite database with the ChromaDex phytochemicals. METLIN is currently the largest repository of metabolite tandem mass spectrometry data. This important class of ChromaDex compounds will expand METLIN's compound library and mass spectrometry data to nutraceuticals and many novel plant-related natural products. The importance in the ChromaDex/METLIN partnership is that it will facilitate metabolomics experiments around the world." states Gary Siuzdak Ph.D, Senior Director, Center for Metabolomics and Mass Spectrometry Scripps Research Institute.
Frank Jaksch, Founder and CSO for ChromaDex, stated "Collaborating with Scripps Research Institute with our natural product libraries will further advance small molecule profiling to increase demand for natural product libraries through the ease of the Internet to assist in finding candidate compounds for research and development."
Screening for Disease or Toxins in a Drop of BloodNews
Scientist have developed a multinozzle emitter array (MEA), a silicon chip that can dramatically shorten the time it takes to identify proteins, peptides, and other molecular components within small volumes of biological samples.READ MORE
Researchers Reveal How Superbug Secretes It’s ToxinNews
Monash University’s Biomedicine Discovery Institute (BDI) researchers have created the first high-resolution structure depicting a crucial part of the ‘superbug’ Pseudomonas aeruginosa. The image identifies the ‘nanomachine’ used by the highly virulent bacteria to secrete toxins, pointing the way for drug design targeting this.READ MORE