ChromaDex® and Scripps Research Institute Collaborate on METLIN Metabolite Database
News Jun 01, 2012
The Scripps METLIN Metabolite Database is a repository of metabolite information that includes tandem mass spectrometry data for over 55,000 unique and potentially therapeutic compounds. It is a public, web-based database designed for the archiving, visualization, and analysis of metabolite data. The information is provided to facilitate metabolomics experiments by providing scientists with a comprehensive source of structures for potential metabolites of their compounds of interest. An annotated list of known metabolites and their mass, chemical formula, and structure are available on the METLIN website. The METLIN database was developed and is maintained by the Siuzdak laboratory at the Scripps Research Institute, La Jolla, California.
Currently, there is limited information for natural products in the database. By expanding the population of data, it will increase the knowledge base and visibility for researchers to screen potential compounds for use in areas of clinical interest, such as cancer, heart disease, diabetes, or Alzheimer's.
"We are very excited about expanding the METLIN metabolite database with the ChromaDex phytochemicals. METLIN is currently the largest repository of metabolite tandem mass spectrometry data. This important class of ChromaDex compounds will expand METLIN's compound library and mass spectrometry data to nutraceuticals and many novel plant-related natural products. The importance in the ChromaDex/METLIN partnership is that it will facilitate metabolomics experiments around the world." states Gary Siuzdak Ph.D, Senior Director, Center for Metabolomics and Mass Spectrometry Scripps Research Institute.
Frank Jaksch, Founder and CSO for ChromaDex, stated "Collaborating with Scripps Research Institute with our natural product libraries will further advance small molecule profiling to increase demand for natural product libraries through the ease of the Internet to assist in finding candidate compounds for research and development."
Bacterial Control Mechanism for Adjusting to Changing ConditionsNews
A fundamental prerequisite for life on earth is the ability of living organisms to adapt to changing environmental conditions. Physicists have now determined that the regulation mechanisms used by bacteria to adapt to different environments are based on a global control process that can be described in a single equation.READ MORE
Cracking the Code of Coenzyme Q BiosynthesisNews
Coenzyme Q is a vital cog in the body’s energy-producing machinery, a kind of chemical gateway in the conversion of food into cellular fuel. Researchers are developing new tools to shed light on CoQ function, primarily by finding and defining proteins that have a direct link to the chemical. This includes the development of a new multi-omic strategy to identify the global function of an RNA-binding protein that has long been associated with mitochondria and its role in CoQ biosynthesis.READ MORE
Changes Identified in Body Cells During Type2 Diabetes OnsetNews
Researchers have found fresh evidence to explain the processes that occur in the body’s cells leading to the onset of type2 diabetes. Utilising metabolomics, results showed that amino acids play a contributory role in the onset of type2 diabetes in some younger and older patients, as the metabolism of specific amino acids is adversely affected.