Compugen Announces Positive Therapeutic Effects of Relaxin Receptor in Pulmonary Fibrosis
News Apr 07, 2009
Compugen has announced that CGEN-25009, a novel peptide that previously demonstrated the ability to activate the Relaxin receptor LGR7 (RXFP1) in cell based assays, has shown positive therapeutic effects in an animal model of pulmonary fibrosis.
The Relaxin receptor is the third G-protein coupled receptor (GPCR) for which Compugen-discovered peptide ligands have shown therapeutic potential in disease models.
“Following two weeks of administration of the CGEN-25009 peptide to mice induced with lung fibrosis, there was a complete reduction in the fibrosis. This improvement was evident both by histology staining and by measuring the Pressure at the Airway Opening (PAO), where levels were comparable to those observed in healthy mice,” said Dr. Anat Cohen-Dayag, vice president, research and development.
“These results suggest that CGEN-25009 prevents pulmonary fibrosis in a disease animal model and therefore could have a potential therapeutic utility to treat pulmonary fibrosis and other fibrosis related conditions, such as chronic renal failure.”
Professor Daniele Bani from the University of Florence, Italy, who performed the animal study and is a recognized world expert in this field with numerous publications on Relaxin’s biology and pathway added, “To my knowledge, this would be the first report on the therapeutic effectiveness of an analogue of Relaxin. In view of the increasing interest in Relaxin as a possible drug and considering the problems inherent in producing enough of this hormone at a reasonably low cost, it could be foreseen that such information would be enthusiastically welcomed.”
Pulmonary fibrosis is a devastating incurable condition, the cause for which is unknown in most cases. It is estimated to affect more than five million people worldwide with tens of thousands of new cases every year in the United States. More than 60% of patients diagnosed with the condition survive less than five years.
CGEN-25009, along with two other Relaxin related peptides, CGEN 25010 and 25011, were among the first peptide ligands predicted and selected utilizing Compugen’s GPCR Ligand Discovery Platform. These peptides were first presented in May 2008 at the 5th International Conference on Relaxin and Related Peptides. Compugen’s initial results suggested that CGEN-25009 has biological activities similar to those of Relaxin, which are now further supported by the in-vivo findings.
Computation and Chemistry Combine to Create World-First Auxetic ProteinNews
A team of chemists at the University of California, San Diego (UCSD) has now designed a two-dimensional protein crystal that toggles between states of varying porosity and density. This is a first in biomolecular design that combined experimental studies with computation done on supercomputers. The research, published in April 2018 in Nature Chemistry, could help create new materials for renewable energy, medicine, water purification, and more.
Fructose Formula Poses Risk to Babies With Metabolic DisorderNews
Babies with inherited intolerance of fructose face a risk of acute liver failure if they are fed certain widely available formulas containing fructose, pediatricians and geneticists are warning. Baby formula manufacturers should remove fructose or sucrose, or explicitly label their products to allow parents to avoid those sweeteners if necessary, the doctors say.