Electrical Control of Cancer Cells
News Aug 26, 2015
The molecular switches regulating human cell growth do a great job of replacing cells that die during the course of a lifetime. But when they misfire, life-threatening cancers can occur. This information is seen as critical in developing treatments for some of the most lethal types of cancer including pancreatic, colon and lung, which are characterized by uncontrolled cell growth caused by breakdowns in cell signaling cascades.
The research focused on a molecular switch called K-Ras. Mutated versions of K-Ras are found in about 20 percent of all human cancers in the United States and these mutations lock the K-Ras switch in the on position.
“When K-Ras is locked in the on position, it drives cell division, which leads to the production of a cancer,” said John Hancock, M.B., B.Chir, Ph.D., ScD, the study’s senior author and chairman of the Department of Integrative Biology and Pharmacology at UTHealth Medical School. “We have identified a completely new molecular mechanism that further enhances the activity of K-Ras.”
The study focused on the tiny electrical charges that all cells carry across their limiting (plasma) membrane. “What we have shown is that the electrical potential (charge) that a cell carries is inversely proportional to the strength of a K-Ras signal,” Hancock said.
With the aid of a high-powered electron microscope, the investigators observed that certain lipid molecules in the plasma membrane respond to an electrical charge, which in turn amplifies the output of the Ras signaling circuit. This is exactly like a transistor in an electronic circuit board.
Yong Zhou, Ph.D., first author and assistant professor of integrative biology and pharmacology at UTHealth Medical School, said, “Our results may finally account for a long-standing but unexplained observation that many cancer cells actively try to reduce their electrical charge.”
Initial work was done with human and animal cells and findings were subsequently confirmed in a fruit fly model on membrane organization.
“This has huge implications for biology,” Hancock said. “Beyond the immediate relevance to K-Ras in cancer, it is a completely new way that cells can use electrical charge to control a multitude of signaling pathways, which may be particularly relevant to the nervous system.”
Computation and Chemistry Combine to Create World-First Auxetic ProteinNews
A team of chemists at the University of California, San Diego (UCSD) has now designed a two-dimensional protein crystal that toggles between states of varying porosity and density. This is a first in biomolecular design that combined experimental studies with computation done on supercomputers. The research, published in April 2018 in Nature Chemistry, could help create new materials for renewable energy, medicine, water purification, and more.
Fructose Formula Poses Risk to Babies With Metabolic DisorderNews
Babies with inherited intolerance of fructose face a risk of acute liver failure if they are fed certain widely available formulas containing fructose, pediatricians and geneticists are warning. Baby formula manufacturers should remove fructose or sucrose, or explicitly label their products to allow parents to avoid those sweeteners if necessary, the doctors say.
Resistance to Antifungals Could Lead to Disease and Global Food ShortagesNews
Growing levels of resistance to antifungal treatments could lead to increased disease outbreaks and affect food security around the world.READ MORE
Comments | 0 ADD COMMENT
World Congress on Bio-organic and Medicinal Chemistry
Nov 12 - Nov 13, 2018