We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
Genetic risk factor for binge eating discovered
News

Genetic risk factor for binge eating discovered

Genetic risk factor for binge eating discovered
News

Genetic risk factor for binge eating discovered

Read time:
 

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "Genetic risk factor for binge eating discovered "

First Name*
Last Name*
Email Address*
Country*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

Researchers have identified a gene (CYFIP2) associated with binge eating.


This finding represents one of the first examples of a genome-wide significant genetic factor to be identified for binge eating in model organisms or humans. In addition, the researchers discovered a network of downregulated genes involved in myelination (the process of forming a sheath around a nerve fiber to allow nerve impulses to move quickly) that also was associated with binge eating.


See Also: Eating disorder gene alters feeding and behavior in female mice


These findings, which appear online in the journal Biological Psychiatry, could potentially lead to treatments targeted to normalize eating behaviors.


Eating disorders are among the most lethal of neuropsychiatric disorders. Compulsive binge eating affects millions of people suffering from eating disorders and obesity in the United States. It is characterized by episodes of eating large quantities of food, often very quickly and to the point of discomfort. Binge eaters often experience a loss of control during the binge as well as shame, distress or guilt afterwards.


Genome-wide association studies of eating disorders in humans have been limited in their power to detect significant associations between genotype and disease or disease traits such as binge eating.


Using gene mapping and gene validation, researchers from Boston University School of Medicine (BUSM) were able to identify cytoplasmic FMR1-interacting protein 2 (CYFIP2) as a major genetic risk factor for binge eating. In addition, they observed that decreased myelination could be a neuropathological consequence of binge eating. "Because we found changes in the brain as a consequence of binge eating that were predictive of decreased myelination, therapeutically promoting remyelination may represent a novel treatment avenue for promoting recovery from negative feeding behaviors in eating disorders," explained corresponding author Camron Bryant, PhD, assistant professor of Pharmacology and Experimental Therapeutics & Psychiatry at BUSM.


Learn More: In anorexia nervosa, brain responds differently to hunger signals


Bryant and his colleagues believe these findings may lead to new therapeutic treatments which could ultimately save lives and restore healthy eating behaviors in conditions such as compulsive overeating, bulimia nervosa, anorexia nervosa and even substance use disorders.


Note: Material may have been edited for length and content. For further information, please contact the cited source.


Boston University Medical Center


Publication

Kirkpatrick SL et al. Cytoplasmic FMR1-Interacting Protein 2 is a Major Genetic Factor Underlying Binge Eating.   Biological Psychiatry, Published Online October 25 2016. doi: 10.1016/j.biopsych.2016.10.021


Advertisement