Horizon Discovery Sign Cancer Metabolomics Service Agreement with GlaxoSmithKline
News Oct 29, 2009
Horizon Discovery (Horizon) has announced it has signed a commercial service agreement with Global Pharmaceutical company; GlaxoSmithKline relating to its X-MAN technology.
Horizon’s X-MAN (Mutant And Normal) cell-line technology provides the first genetically-defined and patient-relevant in vitro models of human cancer. These models are being used by a growing number of Pharma and Biotech companies to accelerate and economize the discovery on new ‘targeted’ or ‘personalized’ cancer medicines.
The agreement contributes to the identification and characterization of novel biomarkers, disease signatures and therapeutic targets in the field of cancer ‘metabolomics’; a rapidly growing area of translational cancer research.
“Dr Chris Torrance, CEO of Horizon says “Horizon uses the power of ‘isogenic’ human cancer models to define how tumors in specific cancer patient-populations become dependent on certain nutrient sources and whether they generate unique metabolite signatures that can be secreted into the bloodstream. In this way, we aim to develop early-detection methods and new classes of ‘personalized’ therapeutics that may starve cancers into submission”
What effects does climate change have on the genetic diversity of living organisms? An international team of researchers studied the genome of the alpine marmot, an ice-age remnant that now lives in large numbers in the high altitude Alpine meadow. Results were unexpected: the species was found to be the least genetically diverse of any wild mammal studied to date.