Kinaxo Contributes its Quantitative Phosphoproteomics Platform to a Drug Efficiency Study
News Feb 26, 2009
Kinaxo Biotechnologies GmbH announced that it was awarded a grant by the Bavarian Research Foundation to expand applications for its quantitative phosphoproteomics platform to contribute to a drug efficacy study.
Quantitative phoshpoproteomics enables analysis of the phosphoproteome, which includes all phosphorylation events occurring in a specific cell line or tissue. Since the majority of targeted small molecules used as anticancer drugs influence the cell’s signal transduction pathways, quantification of phosphorylation patterns in relation to drug administration delivers insights into a compound’s cellular mode of action.
Moreover, non-responsiveness to a multitude of compounds is a fundamental problem in cancer treatment. Here, quantitative phosphoproteomics is a powerful method to unveil the mechanisms of both cellular resistance and a drug’s effect. Furthermore, it can be a valuable tool to discover predictive biomarkers that foretell the therapeutic outcome in a patient which in turn allows a targeted therapy approach.
To develop new methods for individualized tumor therapy in pancreatic cancer, Kinaxo Biotechnologies GmbH has now joined an interdisciplinary collaboration with Priaxon AG, Genomatix Software GmbH, the Technical University Munich and the University Hospital “Rechts der Isar” to perform a large-scale drug efficiency study.
Chinese researchers have developed interfacially polymerized porous polymer particles for low- abundance glycopeptide separation. These polymer particles - with hydrophilic-hydrophobic heterostructured nanopores - can separate low-abundance glycopeptides from complex biological samples with high-abundance background molecules efficiently.