Lactate May Protect Diabetics Against Complications of Hypoglycemia
News Apr 09, 2013
Providing the brain with lactate and potentially other fuels may protect diabetics against life-threatening bouts of hypoglycemia, a Yale study has found.
Both type 1 and type 2 diabetics must tightly control their blood glucose levels to prevent long-term complications of the disease. But the intensive daily regimen of insulin that is required may often result in severe episodes of hypoglycemia, or dangerously low blood sugar levels.
Such episodes may occur without warning or during sleep, and can lead to brain damage, cognitive impairment, or even death.
The Yale team investigated alternates to glucose as fuel sources for the brain to find out if they can help diabetics achieve the necessary tight glycemic control. They infused rodents with lactate and measured levels of indicative chemicals in their brains.
Their results show that lactate helped the animals maintain normal levels of glucose during bouts of hypoglycemia, and helped reverse symptoms associated with acute hypoglycemic attacks.
There may be implications in this study for human diabetics. “Our findings help us understand how brain energy metabolism is altered in the context of hypoglycemia,” explained first author Raimund Herzog, assistant professor of endocrinology at Yale School of Medicine.
Herzog continued, “This study will now guide us in the design of therapies that protect the brain from hypoglycemic injury, thereby permitting tighter control of glucose levels via intensive insulin treatment.”
Bacterial Control Mechanism for Adjusting to Changing ConditionsNews
A fundamental prerequisite for life on earth is the ability of living organisms to adapt to changing environmental conditions. Physicists have now determined that the regulation mechanisms used by bacteria to adapt to different environments are based on a global control process that can be described in a single equation.READ MORE
Cracking the Code of Coenzyme Q BiosynthesisNews
Coenzyme Q is a vital cog in the body’s energy-producing machinery, a kind of chemical gateway in the conversion of food into cellular fuel. Researchers are developing new tools to shed light on CoQ function, primarily by finding and defining proteins that have a direct link to the chemical. This includes the development of a new multi-omic strategy to identify the global function of an RNA-binding protein that has long been associated with mitochondria and its role in CoQ biosynthesis.READ MORE
Changes Identified in Body Cells During Type2 Diabetes OnsetNews
Researchers have found fresh evidence to explain the processes that occur in the body’s cells leading to the onset of type2 diabetes. Utilising metabolomics, results showed that amino acids play a contributory role in the onset of type2 diabetes in some younger and older patients, as the metabolism of specific amino acids is adversely affected.