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Memory-related brain activity loses cohesion as people age
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Memory-related brain activity loses cohesion as people age

Memory-related brain activity loses cohesion as people age
News

Memory-related brain activity loses cohesion as people age

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Groups of brain regions that synchronize their activity during memory tasks become smaller and more numerous as people age, according to a study published in PLoS Computational Biology.


Typically, research on brain activity relies on average brain measurements across entire groups of people. In a new study, Elizabeth Davison of Princeton University, New Jersey, and colleagues describe a novel method to characterize and compare the brain dynamics of individual people.


See Also: Stress hormone elevation associated with working memory deficits in aging


The researchers used functional magnetic resonance imaging (fMRI) to record healthy people's brain activity during memory tasks, attention tasks, and at rest. For each person, fMRI data was recast as a network composed of brain regions and the connections between them. The scientists then use this network to measure how closely different groups of connections changed together over time.


They found that, regardless of whether a person is using memory, directing attention, or resting, the number of synchronous groups of connections within one brain is consistent for that person. However, between people, these numbers vary dramatically.


Related: New clues about the aging brain's memory functions


During memory specifically, variations between people are closely linked to age. Younger participants have only a few large synchronous groups that link nearly the entire brain in coordinated activity, while older participants show progressively more and smaller groups of connections, indicating loss of cohesive brain activity—even in the absence of memory impairment.


"This method elegantly captures important differences between individual brains, which are often complex and difficult to describe," Davison says. "The resulting tools show promise for understanding how different brain characteristics are related to behavior, health, and disease."


Read Next: Researchers find a way to improve memory by suppressing a molecule that links aging to alzheimer’s disease


Future work will investigate how to use individual brain signatures to differentiate between healthily aging brains and brains with age-related impairments.


Note: Material may have been edited for length and content. For further information, please contact the cited source.


PLoS


Publication

Davison EN et al. Individual Differences in Dynamic Functional Brain Connectivity across the Human Lifespan.   PloS Computational Biology, Published November 23 2016. doi: 10.1371/journal.pcbi.1005178


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