Metabolomics Technology Applied to Novel Toxicology Research
News Mar 31, 2009
The paper, titled “Effects of Mainstream Cigarette Smoke on the Global Metabolome of Human Lung Epithelial Cells”, describes the first research study to apply global biochemical profiling to help researchers better understand cellular changes associated with cigarette smoke. Cigarette smoke contains more than 4,000 identified compounds, all in different classes, which makes understanding its cellular impact very complex.
“Metabolon’s technology has been applied to a wide variety of different industries and research areas—many seeking to understand incredibly complex systems,” explained Michael Milburn, chief scientific officer with Metabolon. “In this study, for example, we were able to create a better understanding of cigarette smoke effects on lung epithelial cells.”
The study results, published in the January 22, 2009 issue of Chemical Research in Toxicology, described the use of global biochemical profiling in the study:
“Many of the changed biochemicals were previously reported to be altered by cigarette exposure, but the global metabolomic approach offers the advantage of observing changes to hundreds of biochemicals in a single experiment and the possibility for new discoveries. The metabolomic approach may thus be used as a screening tool to evaluate conventional and novel tobacco products offering the potential to reduce risks of smoking.”
Scientists from the UNC School of Medicine discovered that the anti-inflammatory protein NLRP12 normally helps protect mice against obesity and insulin resistance when they are fed a high-fat diet. The researchers also reported that the NLRP12 gene is underactive in people who are obese, making it a potential therapeutic target for treating obesity and diabetes.READ MORE
Nonalcoholic fatty liver disease produces no noticeable symptoms, but one out of every five people with it will go on to develop a more serious conditions such as nonalcoholic steatohepatosis and cirrhosis. Three new studies investigate how mitochondrial energy production is altered by the progress of fatty liver disease.READ MORE