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Mice Use Fast-Changing Odors To Understand Their Surroundings

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Researchers at the Francis Crick Institute and UCL (University College London) have found that mice can sense extremely fast and subtle changes in the structure of odours and use this to guide their behaviour. The findings, published in Nature today (Wednesday), alter the current view on how odours are detected and processed in the mammalian brain.

Odour plumes, like the steam off a hot cup of coffee, are complex and often turbulent structures, and can convey meaningful information about an animal's surroundings, like the movements of a predator or the location of food sources. But it has previously been assumed that mammalian brains can't fully process these temporal changes in smell because they happen so rapidly, much faster than an animal can sniff.

Using behavioural experiments where mice were exposed to incredibly short bursts of odour, neural imaging, electrophysiology and computer models, the scientists found that mice can, in fact, detect very rapid fluctuations within odour plumes, at rates previously not thought possible. They also showed that mice can use this information to distinguish whether odours are coming from the same or different sources, even if they are very close to each other.

This suggests that the mammalian olfactory system, responsible for the sense of smell, is also key in processing the awareness of physical space and surroundings, guiding decisions important to survival.

Andreas Schaefer, senior author and group leader of the Sensory Circuits and Neurotechnology Laboratory at the Crick and Professor of Neuroscience at UCL says: "From an evolutionary point of view our findings make sense as they help to explain why there is a lot of computational power within the olfactory bulb, the part of the brain where the nose sends signals to. It isn't just processing chemicals from odours but can also calculate information about physical distance and source. It would have been odd for evolution to create such processing power in this part of the brain if it were not being used to help the species survive."

In one key experiment, the scientists trained mice to detect whether two odours were coming from the same source or separate sources. The mice were able to correctly distinguish this difference even when the odours were released in short blips, lasting only a 40th of a second each (40 Hz).

Tobias Ackels, postdoc in the Sensory Circuits and Neurotechnology Laboratory at the Crick says: "Previous research into the sense of smell was done on the assumption that mice couldn't distinguish the fine, fluctuating information in odour plumes.

"We've shown that mice can access and process this information - this opens up a new dimension for studying the brain; we can run experiments that more effectively trigger neurons in a natural way and challenge the olfactory bulb. This will allow us to find out more about how this part of the brain works and how information about the world is extracted by neural circuits."

As part of the study, the scientists designed new technologies including a high speed odour delivery device and equipment that can measure several odours simultaneously with extremely high precision.

These innovations will enable more sophisticated work on the olfactory bulb, increasing our knowledge of how this brain region processes information about the environment and influences behaviour. Ultimately, the team aim to build understanding of how sensory circuits link the external world with internal thought and action.

Reference: Ackels T, Erskine A, Dasgupta D, et al. Fast odour dynamics are encoded in the olfactory system and guide behaviour. Nature. 2021:1-6. doi: 10.1038/s41586-021-03514-2

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