We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
Millennium Initiates Phase II Trial for Diffuse Large B-Cell Lymphoma
News

Millennium Initiates Phase II Trial for Diffuse Large B-Cell Lymphoma

Millennium Initiates Phase II Trial for Diffuse Large B-Cell Lymphoma
News

Millennium Initiates Phase II Trial for Diffuse Large B-Cell Lymphoma

Read time:
 

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "Millennium Initiates Phase II Trial for Diffuse Large B-Cell Lymphoma"

First Name*
Last Name*
Email Address*
Country*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

The Takeda Oncology Company has announced the initiation of a Phase II clinical trial examining rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) with or without VELCADE (bortezomib) for Injection for patients with a common type of lymphoma.

The study will examine previously untreated patients with a genomically defined subtype of lymphoma called non-germinal center B-cell-like (non-GCB) diffuse large B-cell lymphoma.

The non-GCB genomic profile is an important, independent negative prognostic factor for patients with diffuse large B-cell lymphoma. Prior studies have indicated that patients with non-GCB type tumors do not respond well to R-CHOP therapy, which is the current standard of care in this disease setting. This open-label, randomized trial will evaluate whether the addition of VELCADE to R-CHOP (Vc-R-CHOP) improves progression-free survival in the non-GCB patient population.

“This innovative trial is one of our first studies investigating the potential of VELCADE in a genomically defined group of patients,” said Nancy Simonian, M.D., Chief Medical Officer, Millennium. “Millennium was founded in genomic research. This study demonstrates how we ve applied genomic knowledge in clinical trial design to enroll patients most likely to benefit from our therapies.”

VELCADE is currently approved for use in patients with multiple myeloma and relapsed mantle cell lymphoma, a sub-type of NHL. VELCADE has been used by more than 100,000 patients in more than 87 countries worldwide.
Advertisement