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Modified Botulinum Toxin Targets Nerve Cells and Reverses Paralysis in Mice

News   Jan 11, 2021 | Original story from Boston Children's Hospital

 
Modified Botulinum Toxin Targets Nerve Cells and Reverses Paralysis in Mice

The toxin-based delivery platform consists of the modified botulinum toxin at upper left (protease domain in gold, translocation domain in blue, and receptor-binding domain in purple) and the nanobody (the pink tag). When this nanobody-toxin fusion protein binds to the receptor (cyan) on the neuron surface, the cell takes it in through the process of endocytosis, corralling the fusion protein inside a vesicle (light green circle). The toxin's protease domain, carrying the nanobody, then crosses into the interior of the cell. Credit: Sicai Zhang/Dong Lab, Boston Children's Hospital

 
 
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