More than Meets the Eye
News May 29, 2012
These spheres may look almost identical, but subtle differences between them revealed a molecular version of the robots from Transformers. Each sphere is a vesicle, a pod that cells use to transport materials between different compartments.
The images, produced by Marco Faini from John Briggs’ lab at the European Molecular Biology Laboratory (EMBL), in Heidelberg, Germany, are the first high-resolution view of the 3-dimensional structure of such a pod.
They show a particular type of vesicle that is encased by a protein called COPI, and whose structure had never been seen before.
Several copies of the COPI protein attach to each other to form a coat around the vesicle’s membrane.
Briggs and colleagues were surprised to find that the COPI building blocks are capable of a ‘transformer’ act: they can change shape to connect to more or fewer copies of themselves.
So by changing the shape of individual COPI blocks, the cell could create vesicles of different shapes and sizes, for instance to transport different kinds of cargo.
Previously, scientists had been able to create and determine the structure of ‘cages’ formed by parts of the protein coats that encase other types of vesicles, but this study, published online in Science, was the first to obtain high-resolution images of complete vesicles, budded from a membrane.
The work was carried out in collaboration with the lab of Felix Wieland at Heidelberg University in Germany.
Animal venoms are the subject of study at research center based at the Butantan Institute in São Paulo. But in this case, the idea is not to find antidotes, but rather to use the properties of the venoms themselves to identify molecular targets of diseases and, armed with that knowledge, develop new compounds that can be used as medicines.