Multinational deCODE Study Identifies New Link between Inflammation and Heart Attack
News Feb 10, 2009
In a paper published, scientists at deCODE genetics and academic colleagues from four continents present a novel insight into the connection between inflammation and heart disease.
Through a genome-wide search in some 10,000 Icelanders, the deCODE team discovered several common single-letter variations in the sequence of the human genome (SNPs) that increase levels of eosinophils in the bloodstream. These are a type of white blood cell that fights parasite infection and mediates inflammation.
One of these SNPs, located on chromsome 12q24, was then shown to confer increased risk of heart attack through analysis of the genomes of more than 46,000 patients and controls from Iceland, New Zealand, Italy, and the United States. Given the established role of eosinophils in asthma, the deCODE team also analyzed the eosinophil SNPs in more than 50,000 asthmatics and healthy control subjects from the countries above as well as from Germany, Sweden, Australia, and South Korea. A SNP on chromosome 2q12 was associated with increased risk of asthma, and three other SNPs were associated with risk of atopic asthma.
Computation and Chemistry Combine to Create World-First Auxetic ProteinNews
A team of chemists at the University of California, San Diego (UCSD) has now designed a two-dimensional protein crystal that toggles between states of varying porosity and density. This is a first in biomolecular design that combined experimental studies with computation done on supercomputers. The research, published in April 2018 in Nature Chemistry, could help create new materials for renewable energy, medicine, water purification, and more.
Fructose Formula Poses Risk to Babies With Metabolic DisorderNews
Babies with inherited intolerance of fructose face a risk of acute liver failure if they are fed certain widely available formulas containing fructose, pediatricians and geneticists are warning. Baby formula manufacturers should remove fructose or sucrose, or explicitly label their products to allow parents to avoid those sweeteners if necessary, the doctors say.
4000-Year Old DNA Helps Track the Spread of Rice Farming in AsiaNews
Rice farming spread far and wide in ancient Southeast Asia, but how it got there has been a mystery. Now, a study of 4000-year-old DNA—a rare find in this region—suggests it came with farmers migrating from China, where rice farming originated.
Comments | 0 ADD COMMENT
Epigenetics in the nervous system: development and disease
Oct 01 - Oct 03, 2018