Nerve "Insulating Fiber" Required for Touch and Pain Sensation
This discovery opens new avenues for pain therapy.
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The first indications of the importance of Schwann cells in pain perception (nociception) came from earlier studies by Lewin’s Swedish collaborators. This prompted Julia Ojeda-Alonso from the Lewin lab and Poulet’s lab to team up with international colleagues like Dr Laura Calvo-Enrique from the Karolinska Institutet in Stockholm – in order to get to the bottom of the matter. Using a technique called optogenetics, the researchers bred mice in which they were able to switch different types of Schwann cells on and off with different colors of light.
Without Schwann cells, the mice could not sense vibrations
All it took to convey pain sensations to the brain was to activate the Schwann cells with a light stimulus. It was not necessary to stimulate the actual nociceptors. When the Schwann cells were blocked, the transmission of stimuli by nociceptors was reduced by at least half. “We assume that technical limitations prevented us from being able to fully map the role of Schwann cells and that in some cases they actually perform most of the stimulus detection ,” says Lewin.
The team next ran experiments with tactile stimuli. They focused on the Meissner corpuscles, which are vibration receptors in the skin that are closely associated with Schwann cells. The team led by James Poulet, who heads the Neural Circuits and Behavior Lab at the Max Delbrück Center, trained the mice to sense tiny vibrations with their forepaw and to report detection of these stimuli. “When the Schwann cells were switched off, it was much more difficult for mice to do this,” explains Poulet. After the optogenetic blockade was removed, their ability to sense tiny skin vibrations returned.
New approaches for pain therapy
The researchers showed that the Schwann cells primarily influence the transmission of mechanical stimuli, but not heat or cold stimuli. “It may be that polymodal nociceptors, which react to mechanical, thermal and chemical stimuli, only function properly with the help of Schwann cells,” says Lewin.
The results open new avenues for understanding and treating pain and impaired touch perception. “The Schwann cells just below the surface of the skin are easily accessible to therapeutic agents,” says Lewin. “This makes them an attractive target for tackling the problem right at the root.”
Reference: Ojeda-Alonso J, Calvo-Enrique L, Paricio-Montesinos R, et al. Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception. Nat Commun. 2024;15(1):898. doi: 10.1038/s41467-024-44845-8
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