We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement

Neural Circuits That Kickstart Maternal Behavior Identified

A woman in a black and white striped top holds an infant.

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "Neural Circuits That Kickstart Maternal Behavior Identified"

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

Read time:
 

Various conditions such as postpartum depression or postpartum psychosis can lead to an alteration in maternal behaviour and disrupt the mother-child bonding process. A research team led by Daniela Pollak from MedUni Vienna's Center for Physiology and Pharmacology has conducted a study in which they were able to identify the neuronal circuits in the brain that are activated during the learning of maternal behaviour. The findings, published in The EMBO Journal, can serve as a basis for developing therapeutic interventions.


In the course of their preclinical investigation, the scientists led by Daniela Pollak from the Division of Neurophysiology and Neuropharmacology at MedUni Vienna's Center for Physiology and Pharmacology analysed maternal behaviour of female mice towards newborn pups. While the neural processes involved in the development of maternal care behaviour in female mice after birth have already been described, the current study addressed the question which circuits in the brain are activated during the learning of care behaviour in nulliparous virgin females, female mice that have not been pregnant.


The researchers found the answer in the anterior cingulate cortex (ACC), a region in the prefrontal lobe of the brain that is associated, among other things, with the recognition and evaluation of social processes and the development of emotional awareness. The mouse model showed that in females who have not been pregnant or given birth, the ACC gets activated when they acquire maternal behaviour upon first contact with pups. "Our observations have demonstrated that, through repeated experience with pups, the virgin females are capable of learning maternal behaviour that fully resembles those of mothers after delivery," explains project leader Daniela Pollak, reporting from her research. The study revealed that during this learning process ACC activity is controlled by an excitatory feedback circuit involving a specific group of neurons in a central brain region (the thalamus).

Learning through repeated experience

Maternal behaviour is defined, among other things, by sensitivity and responsiveness to signals of infant needs. It is instinctively displayed in virtually all mammals and upon first contact with newborns immediately after delivery. In some species, such as rodents, even animals that have never given birth may exhibit maternal care behaviour toward newborns. In this case, the care behaviour, such as returning displaced pups from outside the nest back into the nest area, where they are warm and protected from predators, are acquired through repeated experience with the pups.


We know, for example from observations in adoptive parents, that humans can also learn parental behaviours. Various pathological conditions, such as postpartum depression or postpartum psychosis can lead to alterations in maternal behaviour and disrupt the mother-child bonding process. "By showing that maternal behaviours can be acquired and identifying the underlying neuronal circuits in the brain that control this acquisition, we are creating a potential basis for developing therapeutic options for these clinical situations," says Daniela Pollak, outlining the translational relevance of the study results, which were obtained in collaboration with Tibor Harkany from the Division of Molecular Neurosciences at MedUni Vienna's Center for Brain Research.


Reference: Glat M, Gundacker A, Cuenca Rico L, et al. An accessory prefrontal cortex–thalamus circuit sculpts maternal behavior in virgin female mice. The EMBO Journal. 2022;n/a(n/a):e111648. doi:10.15252/embj.2022111648


This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

Advertisement